Registration Dossier

Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics
Adequacy of study:
key study
Study period:
2002
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
review article or handbook
Title:
Ganong`s Review of Medical Physiology
Author:
Barrett KE et al.
Year:
2016
Bibliographic source:
McGraw-Hill Education

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Preliminary studies:
Calcium chloride is easily dissociated into calcium and chloride ions in water. The absorption, the distribution and the excretion of the ions in animals and humans are regulated separately. Calcium and chloride are essential constituents of the body of all animal species including humans. Calcium is essential for the formation of skeletons and the regulation of neural transmission, muscle contraction and coagulation of the blood. Chloride is required for regulating intracellular osmotic pressure and buffering. The homeostasis and mechanisms of action of calcium and chloride ions are extensively reviewed in textbooks on pharmacology, physiology, biochemistry and nutritional science.

Applicant's summary and conclusion