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Guidance on Safe Use

Guidance on Safe Use

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Administrative data

First-aid measures

See attached SDS below

Fire-fighting measures

See attached SDS below

Accidental release measures

See attached SDS below

Handling and storage

See attached SDS below

Transport information

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Marine transport (UN RTDG/IMDG)

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Exposure controls / personal protection

STADEX NEDERLAND BV

SAFETY DATA SHEET
According to 1907/2006/EC, article 31 (REACH) and according to 1272/2008/EC (CLP)

GLYCIDYL METHACRYLATE

1 IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND COMPANY/UNDERTAKING

PRODUCT NAME 2,3-epoxypropyl methacrylate

TRADE NAMES glycidyl methacrylate, GMA

REACH REGISTRATION NUMBER 01-2119444916-30-0000

SUPPLIER STADEX NEDERLAND BV
Boxbergerweg 119
7431PM Diepenveen, The Netherlands
Phone +31 611923166
Email randerhoftrading@hotmail.com

EMERGENCY TELEPHONE +31 611923166 (office hours only)

2 HAZARDS IDENTIFICATION

Glycidyl methacrylate is used as industrial feedstock for further synthesis (mainly polymerisation).


LABELLING DANGER

CLASSIFICATION (index number 607-123-00-4)
Glycidyl methacrylate is classified as:
acute toxicity oral category 4
acute toxicity dermal category 3
eye damage category 1
skin corrosion category 1C
skin sensitisation category 1A
specific target organ toxicity, single exposure category 3 (may cause respiratory irritation)
specific target organ toxicity, repeated exposure category 1 (respiratory tract)(inhalation)
carcinogenic category 1B
germ cell mutagenic category 2
toxic to reproduction category 1B

The substance is usually stabilised with about 100 ppm of the polymerisation inhibitor mequinol (EC #205-769-8, CAS #150-76-5).




3 COMPOSITION/INFORMATION ON INGREDIENTS

Name EC-No CAS-No Content Hazard statements
Glycidyl methacrylate 203-441-9 106-91-2 >99% H302,311,314,317,341,350,360F,335,372

The product does not contain impurities or additives that could affect product’s labelling and classification.
The Full Text for all Hazard Statements are Displayed in Section 16

COMPOSITION COMMENTS
The Data shown are in accordance with the latest EU Directives

4 FIRST-AID MEASURES

INHALATION
Move any exposed person to fresh air at once. Keep warm and at rest. If there is respiratory distress give oxygen. If respiration stops or shows signs of failing, apply artificial respiration (if by mouth to mouth: use rescuer protection such as pocket mask, etc).
Get medical attention immediately.

INGESTION
Wash out mouth with water and give plenty of water to drink, provided person is conscious. Do not induce vomiting.
Get medical attention immediately.

SKIN CONTACT
Immediately wash skin with plenty of running water and non-abrasive soap, under a shower if affected area is large enough to warrant this, while removing contaminated clothing and shoes.
Get medical attention immediately
Destroy contaminated leather items such as shoes, belts, and watchbands. First Aid responders should pay
attention to self-protection and use the recommended protective clothing (chemical resistant gloves, splash protection).

EYE CONTACT
Rinse immediately eye with plenty of low pressure water for at least 30 minutes.
Remove any contact lenses.
Get medical attention immediately preferably from an ophthalmologist.

NOTES TO PHYSICIAN
Due to irritant properties, swallowing may result in burns/ulceration of mouth, stomach and lower gastrointestinal tract with subsequent stricture. Aspiration of vomitus may cause lung injury. Suggest endotracheal / oesophageal control if lavage is done. Respiratory symptoms, including pulmonary oedema, may be delayed. Persons receiving significant exposure should be observed 24-48 hours for signs of respiratory distress. Maintain adequate ventilation and oxygenation of the patient. Chemical eye burns may require extended irrigation. Obtain prompt consultation, preferably from an ophthalmologist. If burn is present, treat as any thermal burn, after decontamination. No specific antidote. Treatment of exposure should be directed at the control of symptoms and the clinical condition of the patient.

Medical Conditions Aggravated by Exposure:
Excessive exposure may aggravate pre-existing asthma and other respiratory disorders (e.g. emphysema, bronchitis, reactive airways dysfunction syndrome).

5 FIRE-FIGHTING MEASURES

EXTINGUISHING MEDIA
Glycidyl methacrylate is a combustible liquid (class IIIA).
For small fires, use dry chemical, carbon dioxide, water spray or foam. Alcohol resistant foams (ATC type) are preferred. General purpose synthetic foams (including AFFF) or protein foams may function, but will be less effective.
For large fires, use water spray, fog, or foam. Use water spray to cool fire-exposed containers. Do NOT use straight streams of water.

SPECIAL FIRE FIGHTING PROCEDURES
Keep people away. Isolate fire and deny unnecessary entry. Use water spray to cool fire exposed containers and fire affected zone until fire is out and danger of re-ignition has passed. Fight fire from protected location or safe distance. Consider the use of unmanned hose holders or monitor nozzles. Immediately withdraw all personnel from the area in case of rising sound from venting safety device or discoloration of the container. Do not use direct water stream. May spread fire. Move container from fire area if this is possible without hazard. Burning liquids may be moved by flushing with water to protect personnel and minimize property damage. Water fog, applied gently may be used as a blanket for fire extinguishment.

UNUSUAL FIRE & EXPLOSION HAZARDS
Container may rupture from gas generation in a fire situation.
Violent steam generation or eruption may occur upon application of direct water stream to hot liquids.

SPECIFIC HAZARDS
During a fire, smoke may contain the original material in addition to combustion products of varying composition which may be toxic and/or irritating. Combustion products may include and are not limited to: Carbon monoxide and Carbon dioxide.

PROTECTIVE MEASURES IN FIRE
Wear positive-pressure self-contained breathing apparatus (SCBA) and protective fire fighting clothing (includes fire fighting helmet, coat, trousers, boots, and gloves). Avoid contact with this material during fire fighting operations. If contact is likely, change to full chemical resistant fire fighting clothing with self-contained breathing apparatus. If this is not available, wear full chemical resistant clothing with self-contained breathing apparatus and fight fire from a remote location. For protective equipment in post-fire or non-fire clean-up situations, refer to the relevant sections of this SDS.

6 ACCIDENTAL RELEASE MEASURES

PERSONAL PRECAUTIONS
See section 8.
Evacuate area. Only trained and properly protected personnel must be involved in clean-up operations. Keep upwind of spill. Ventilate area of leak or spill.

ENVIRONMENTAL PRECAUTIONS
Take precautionary measures against discharges into the environment.

SPILL CLEAN UP METHODS
Contain spilled material if possible and dike area to contain spill.
Absorb spill with inert material (e.g. polyethylene or polypropylene fiber products, sand or earth), then place in suitable container with shovel.
Do NOT use absorbent materials such as: cellulose, clay, sawdust, Milsorb®. Drierite, Absorn-n-dri.
Clean up spills immediately, observing precautions in the Protective Equipment section.

7 HANDLING AND STORAGE

USAGE PRECAUTION
Only to be handled and used under very well controlled conditions in closed systems as industrial feedstock for further synthesis (mainly polymerisation)
Do not get on skin or clothing. Do not swallow. Avoid contact with eyes. Use only in a well-ventilated area and avoid inhalation.
Glycidyl methacrylate is stable under recommended storage conditions. Elevated temperatures can cause hazardous polymerisation. Polymerisation can be catalysed by the absence of air, the presence of free radical initiators and peroxides, acids, UV light, bases or high temperature. GMA usually contains an inhibitor (stabiliser) to minimise polymerisation (ca 100 ppm mequinol CAS #150-76-5, EC #205-769-8).

Wash thoroughly after handling. Empty containers retain product residue, (liquid and/or vapour), and can be dangerous. Keep container tightly closed. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.

STORAGE PRECAUTIONS
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store away from direct sunlight or UV light. Use containers from non-UV transmitting material. Maintain inhibitor and dissolved oxygen level. Do not purge containers of this material with nitrogen. Uninhibited monomer vapours can polymerize and plug relief devices.
Shelf life: Use within 12 months
Storage temperature: < 25 °C

8 EXPOSURE CONTROLS/PERSONAL PROTECTION/USE LIMITS/SUMMARY OF RMM’s

EXPOSURE LIMITS
None listed.

USE LIMITS
Only to be handled and used under very well controlled conditions in closed systems as industrial feedstock for further synthesis.

PNECs (see also section 12)
PNEC Aqua freshwater 0.01 mg/L Sediment freshwater 0.09 mg/kg sediment dw
Marine water 0.001 mg/L Sediment marine water 0.009 mg/kg sediment dw
Sewage treatment plant 10 mg/L Agricultural soil 0.09 mg/kg soil dw

DNELs/DMELs
The main derived long-term DNELs/DMELs for long term systemic effects for glycidyl methacrylate are:
Workers General population Type
Oral not relevant 2.3 µg/kg bw/day DMEL
Dermal 12.76 µg/kg bw/day 2.3 µg/kg bw/day DMEL
Inhalation 45 µg/m3 4.0 µg/m3 DMEL

The CHESAR v2.3 tool and exposure model for this substance shows for indoor industrial activities taking more than 4 hours/day, with local exhaust ventilation (LEV) present (and running), provided workers wear masks with at least 95% respiratory protection and gloves with at least 95%/99% dermal protection, the following exposures:

Inhalation dermal RCR RCR RCR Dermal Max nr of
mg/m3 mg/kg/d inhalation dermal total protection working hours
PROC1 0.002 0.002 0.046 0.133 0.179 95% 8
Use in closed process, no likelihood of exposure
PROC2 0.021 0.007 0.461 0.537 0.998 95% 8
Use in closed, continuous process with occasional controlled exposure
PROC3 0.012 0.003 0.276 0.269 0.545 95% 1
Use in closed batch process (synthesis or formulation)
PROC8b 0.01 0.0068 0.230 0.538 0.768 99% 1
Transfer of chemicals from/to vessels/large containers at dedicated facilities
PROC9 0.021 0.0068 0.461 0.538 0.999 99% 1
Transfer of chemicals into small containers (dedicated filling line)
PROC15 0.021 0.002 0.461 0.133 0.594 95% 1
Use as laboratory reagent

The applied RMMs/OCs will also control the risks relating to skin & eye damage / corrosion (H314) and skin sensitisation (H317).
Notes:
• The outcome of ECETOC TRA v3 (10 April 2012) is identical to CHESAR v2.3
• Good general ventilation is assumed in all cases (3-5 air exchanges per hour)
• PROC4 (Use in batch and other process (synthesis) where opportunity for exposure arises) is not shown but gives the same results as PROC9
• PROC1, PROC2 and PROC15 require gloves with at least 95% dermal protection, and all other PROCs 99%
• LEV is considered for both inhalation and dermal exposures and its efficiencies are as follows:
o For PROC1 LEV is not an exposure modifier
o For PROC2, PROC3, PROC9 and PROC15 LEV reduces both inhalation and dermal exposure with 90%
o For PROC8b LEV reduces both inhalation and dermal exposure with 95%
• The number of working hours is determined by the inhalation exposure
o PROC 3, 8b, 9 and 15 are only allowed for less than 1 hour activity per day
• Professional and consumer use is strictly forbidden

Consumer exposure: Glycidyl methacrylate is produced, handled and used in a closed system under very well controlled conditions at industries as monomer for the synthesis of polymers and as an intermediate for further chemical synthesis. Therefore consumer exposure will be very limited.

GENERAL
At all times strict engineering controls should prevent direct exposure (even accidental) to GMA. However, as an extra measure in case these engineering controls would fail, respiratory and skin protection as mentioned below are required. Personal protective equipment can never be an alternative to engineering controls but is always additional. GMA is only approved and registered for a very limited number of industrial uses. Professional and consumer uses are forbidden.

MAXIMUM DURATION OF ACTIVITY
For PROC3, 8b, 9 and 15 max 1 hour per day.

PROTECTIVE EQUIPMENT
Protective gloves, boots, safety goggles, respiratory mask and protective clothing.

RESPIRATORY EQUIPMENT
Wear positive pressure self-contained breathing apparatus classified under EN 137:2006 and give operators specific training. Cartridges must be discarded after each working day.

HAND PROTECTION
Wear appropriate protective gloves to prevent skin exposure. Use chemically resistant gloves classified under EN 374, class 6 (breakthrough time > 480 minutes) and made of butyl rubber with a minimal thickness of 0.3 mm (preferably 0.7 mm). Give operators specific training. An advanced occupational health and safety management system must be in use. Discard gloves after one working day or when they have come into direct contact with the substance.

EYE PROTECTION
Wear approved safety goggles classified under EN 166:2001.

HYGIENE MEASURES
Wash at the end of each work shift and before eating, drinking, smoking or using the toilet.

SKIN PROTECTION
Wear protective clothing and boots.

9 PHYSICAL AND CHEMICAL PROPERTIES

APPEARANCE liquid

COLOUR clear and colourless

ODOUR fruity (ester-like)

FLASH POINT 76° C (closed cup)
84° C (open cup)

AUTOIGNITION TEMPERATURE 389 ° C

MELTING POINT -41.5 ° C

BOILING POINT 189 ° C

RELATIVE DENSITY (LIQUID) 1.07 kg/m3 @ 25 ° C

VAPOUR PRESSURE 4.2 x 100 Pa @ 25 ° C

SURFACE TENSION 0.025 N/m @ 20 ° C

WATER SOLUBILITY ca 50 gram/litre @ 25 ° C

PARTITION COEFFICIENT Log P (octanol/water) = 0.96 @ 25 ° C

VISCOSITY 5.481 cP @ 21 ° C

10 STABILITY AND REACTIVITY

STABILITY
Combustible liquid. Stable at room temperature. However, it may undergo explosive polymerization if uninhibited.

MATERIALS TO AVOID
Avoid unintended contact with activated carbon or silica gel, as this may cause polymerisation. Also avoid contact with cellulose or clay based absorbents, and with incompatible materials such as oxidising or reducing agents, strong acids and bases, metals (cast iron, mild steel, copper, brass) and metal oxides.

CONDITIONS TO AVOID
Incompatible materials, ignition sources.

HAZARDOUS DECOMPOSITION PRODUCTS
(CO)x, carbon monoxide, carbon dioxide.

11 TOXICOLOGICAL INFORMATION

ACUTE TOXICITY
Dermal, rabbit: LD50 = 480 mg/kg
Inhalation, rat: LC0 = 2394 mg/m3/4H
Oral, rat: LD50 = 597 mg/kg

CARCINOGENICITY
Glycidyl methacrylate is due to its metabolism to glycidol carcinogenic category 1B. The T25 is 57 mg/kg bw/d.

INHALATION
May cause respiratory tract irritation.

INGESTION
Harmful if swallowed. Swallowing may result in gastrointestinal irritation or ulceration. Swallowing
may result in burns of the mouth and throat. Aspiration into the lungs may occur during ingestion or
vomiting, causing tissue damage or lung injury.

SKIN CONTACT
Toxic in contact with skin. May be absorbed through the skin in toxic amounts.
Causes skin corrosion.
May cause skin sensitisation.

EYE CONTACT
Causes serious eye damage.
May cause severe corneal injury. Effects may be slow to heal. Vapour may cause corneal injury.

TOXICOKINETCS, METABOLISM, DISTRIBUTION
In rabbits, after an iv injection of 200 mg/kg, more than 95% of the substance disappeared from the blood within 10 minutes. It is quickly metabolised by the carboxyl esterase route to glycidol.

REPEATED DOSE TOXICITY
The major toxicity is tissue damages in the first exposure sites such as the fore stomach after oral administration and the respiratory tract after inhalation, due to irritation.

GENOTOXICITY
Most in vitro genotoxicity studies show positive results. In an in vivo micronucleus test, oral administration of glycidyl methacrylate increased the frequency of micronucleated polychromatic erythrocytes only at the highest dose (750 mg/kg in male and 1000 mg/kg in female mice), although mostly negative results were shown in other in vivo genotoxicity studies including micronucleus tests by intraperitoneal administration. Glycidol, a metabolite of glycidyl methacrylate, is classified as a Category 2 germ cell mutagen under REACH and CLP. Based on the available studies for glycidyl methacrylate itself and data for glycidol , glycidyl methacrylate is considered to be a substance with genotoxic potential.

TOXICITY TO REPRODUCTION
In rat studies a decreased fertility index (number of delivered animals / number of mated animals) was seen at 100 mg/kg. This is supported by studies in mice showing an increase in the percentage of abnormal sperm and decrease in the number of sperm. GMA is classified as toxic to reproduction category 1B.

DEVELOPMENTAL TOXICITY
No teratogenic effects were seen, not even at dose levels which caused maternal toxicity.

12 ECOLOGICAL INFORMATION

ECOTOXICITY

LC50 (freshwater fish, 96h): 2.8 mg/l
EC50 (Daphnia, 48h): 24.9 mg/l
EC50 (Algae, 72h): 14.6 mg/l

Acute and chronic toxicity data of glycidyl methacrylate to aquatic organisms are summarized as follows:
As the lowest acute and chronic toxicity data, 14 day LC50 of Oryzias latipes (1.9 mg/l) and 21 day NOEC (reproduction) of Daphnia magna were selected (1.02 mg/l), respectively.
An assessment factor of 100 was chosen and applied to the chronic toxicity data to determine PNEC, because chronic toxicity data for fish were not available. Thus, PNEC (aqua fresh-water) of gycidyl methacrylate is 0.01 mg/l.
The CHESAR v2.3 tool predicts the following for the relevant ERCs 1/2/6a/6c/6d (with fraction of tonnage to region = 1):
ERC1 ERC2 ERC6a/6c ERC6d
PEC RCR PEC RCR PEC RCR PEC RCR
PEC for local freshwater 0.01 0.968 0.01 0.968 0.01 0.968 6.7e-5 0.007
mg/l
PEC for freshwater sediment 0.067 0.743 0.067 0.743 0.067 0.743 4.63e-4 0.005
mg/kg dw
PEC for marine water (mg/l) 0.001 0.968 0.001 0.968 0.001 0.968 6.6e-6 0.007
mg/l
PEC for marine water sediment 0.007 0.743 0.007 0.743 0.007 0.743 4.54e-5 0.005
mg/kg dw
PEC for STP 0.097 0.01 0.097 0.01 0.097 0.01 6.04e-4 6.0e-5
mg/l
PEC for agricultural soil 0.004 0.045 0.004 0.047 0.004 0.043 0.001 0.014
mg/kg dw
Man via the environment n.a. 0.509 n.a. 0.665 n.a. 0.394 n.a. 0.964
total

Max tonnage to be used per day 1 3 7.5 7.5
Maximum tonnage to be used per year 350 1000 2500 1250

ERC1 = manufacture
ERC2 = formulation
ERC6a = Industrial use as intermediate for further processing (not under strictly controlled conditions)
ERC6c = Industrial use of monomers for manufacture of thermoplastics
ERC6d = Industrial use of process regulators for polymerisation processes in production of resins, rubbers, polymers

Note: the RMMs / OCs are a sewage treatment plant with 67.77% efficiency. ERC1 and ERC2 require filtration/scrubbing with an effectiveness of 99% water / 90% air (ERC 6a/6c/6d require 99% water / 99% air).

Glycidyl methacrylate is not a Persitent/Bioaccumulative (PB) or a veryPersitent/veryBioaccumulative (vP/vB) substance, and readily biodegradable but not meeting the 10 day window. It is Toxic (T).

WATER HAZARD CLASSIFICATION
According to the German VwVwS: WGK: 1 (low danger for water pollution)

13 DISPOSAL CONSIDERATIONS

GENERAL INFORMATION
Place into a suitable closed container for disposal.

DISPOSAL METHODS
Dispose of in accordance with local and national regulations. This product, when being disposed of in its unused and uncontaminated state should be treated as a hazardous waste. Do not dump into any sewers, on the ground, or into any body of water. DO NOT CUT, DRILL, GRIND, WELD OR PERFORM SIMILAR OPERATIONS ON OR NEAR CONTAINERS EVEN WHEN EMPTY.

14 TRANSPORT INFORMATION

GENERAL
The product is covered by international regulations on the transport of dangerous goods under UN DOT, hazard class 6.1 (toxic substance)

UN ADR RID IMDG ICAO
UN number 2810 2810 2810 2810 2810
Class 6.1 6.1 6.1 6.1 6.1
Packing group III III III III III
Transport category 6.1 6.1
Hazard label 6.1 6.1

15 REGULATORY INFORMATION

A Chemical Safety Assessment has been carried out.

LABELLING danger (GHS05, GHS06, GHS08)

CONTAINS 2,3-epoxypropyl methacrylate (>99%)

HAZARD STATEMENTS
H302: Harmful if swallowed.
H311: Toxic in contact with skin.
H314: Causes severe skin burns and eye damage.
H317: May cause an allergic skin reaction.
H341: Suspected of causing genetic defects.
H350: May cause cancer.
H360F: May damage fertility.
H335: May cause respiratory irritation.
H372: Causes damage to the respiratory tract through prolonged or repeated inhalation.

PRECAUTIONARY STATEMENTS
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P272: Contaminated work clothing should not be allowed out of the workplace.
P363: Wash contaminated clothing before reuse.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P301+P330+P331: IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing
P310: Immediately call a POISON CENTER or doctor/physician.
P312: Call a POISON CENTER/ doctor/…/if you feel unwell
P314: Get Medical advice/attention if you feel unwell.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P322: Specific measures (see on this label).
P308+P313: IF exposed or concerned: Get medical advice/attention.
P403+P233: Store in a well ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container in accordance with local and national regulations

16 OTHER INFORMATION

ISSUED BY HS&E Manager

REVISION DATE: 10/12/2014

HAZARD STATEMENTS
H302: Harmful if swallowed.
H311: Toxic in contact with skin.
H314: Causes severe skin burns and eye damage.
H317: May cause an allergic skin reaction.
H341: Suspected of causing genetic defects.
H350: May cause cancer.
H360F: May damage fertility.
H335: May cause respiratory irritation.
H372: Causes damage to the respiratory tract through prolonged or repeated inhalation.



Stability and reactivity

See attached SDS above

Disposal considerations

See attached SDS above