Registration Dossier
Registration Dossier
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EC number: 203-441-9 | CAS number: 106-91-2
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No GLP and no specified test guideline
Data source
Referenceopen allclose all
- Title:
- No information
- Author:
- Dorothy
- Year:
- 1 986
- Bibliographic source:
- Dorothy, A.C. et al., Mutat.Res., 172, 105-138 (1986)
- Title:
- No information
- Author:
- OECD
- Year:
- 1 999
- Bibliographic source:
- OECD SIDS for glycidyl methacrylate, December 1999
Materials and methods
Test guideline
- Guideline:
- other: bacterial reverse mutation assay
- GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 2,3-epoxypropyl methacrylate
- EC Number:
- 203-441-9
- EC Name:
- 2,3-epoxypropyl methacrylate
- Cas Number:
- 106-91-2
- Molecular formula:
- C7H10O3
- IUPAC Name:
- oxiran-2-ylmethyl methacrylate
- Details on test material:
- Produced by Aldrich, purity 98%
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- other: Salmonella typhimurium TA97, TA98, TA100, TA1535
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9 from hamster liver, induced with aroclor 1254-induced, or rat liver induced with aroclor 1254
- Test concentrations with justification for top dose:
- 0, 10, 33, 100, 333, 1000 micogram/plate
Controls
- Positive controls:
- yes
- Positive control substance:
- other: With metabolic activation: 2-aminoanthracene (all strains) Without metabolic activation: sodium azide (TA 100, TA 1535), 9aminoacridine (TA 97), 4-nitro-o-phenylenediamine (TA 98)
- Details on test system and experimental conditions:
- Number of replicates: once at least.
Plates/test: 3 - Statistics:
- Not reported
Results and discussion
Test results
- Species / strain:
- other: Salmonella typhimurium TA97, TA98, TA100, TA1535
- Metabolic activation:
- with and without
- Genotoxicity:
- positive
- Cytotoxicity / choice of top concentrations:
- other: unknown
- Additional information on results:
- Glycidyl methacrylate showed positive result in TA97, TA100, TA1535 with and without metabolic activation but not in TA98.
Conclusions: Bacterial gene mutation is positive with and without metabolic activation. - Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
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