Registration Dossier
Registration Dossier
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EC number: 203-441-9 | CAS number: 106-91-2
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No GLP and no specified test guideline
Data source
Referenceopen allclose all
- Title:
- No information
- Author:
- Dorothy
- Year:
- 1 986
- Bibliographic source:
- Dorothy, A.C. et al., Mutat.Res., 172, 105-138 (1986)
- Title:
- No information
- Author:
- OECD
- Year:
- 1 999
- Bibliographic source:
- OECD SIDS for glycidyl methacrylate, December 1999
Materials and methods
Test guideline
- Guideline:
- other: bacterial reverse mutation assay
- GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 2,3-epoxypropyl methacrylate
- EC Number:
- 203-441-9
- EC Name:
- 2,3-epoxypropyl methacrylate
- Cas Number:
- 106-91-2
- Molecular formula:
- C7H10O3
- IUPAC Name:
- oxiran-2-ylmethyl methacrylate
- Details on test material:
- Produced by Aldrich, purity 98%
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- other: Salmonella typhimurium TA97, TA98, TA100, TA1535
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9 from hamster liver, induced with aroclor 1254-induced, or rat liver induced with aroclor 1254
- Test concentrations with justification for top dose:
- 0, 10, 33, 100, 333, 1000 micogram/plate
Controls
- Positive controls:
- yes
- Positive control substance:
- other: With metabolic activation: 2-aminoanthracene (all strains) Without metabolic activation: sodium azide (TA 100, TA 1535), 9aminoacridine (TA 97), 4-nitro-o-phenylenediamine (TA 98)
- Details on test system and experimental conditions:
- Number of replicates: once at least.
Plates/test: 3 - Statistics:
- Not reported
Results and discussion
Test results
- Species / strain:
- other: Salmonella typhimurium TA97, TA98, TA100, TA1535
- Metabolic activation:
- with and without
- Genotoxicity:
- positive
- Cytotoxicity / choice of top concentrations:
- other: unknown
- Additional information on results:
- Glycidyl methacrylate showed positive result in TA97, TA100, TA1535 with and without metabolic activation but not in TA98.
Conclusions: Bacterial gene mutation is positive with and without metabolic activation. - Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
