Registration Dossier
Registration Dossier
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EC number: 203-441-9 | CAS number: 106-91-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Title:
- No information
- Author:
- Olson
- Year:
- 1 960
- Bibliographic source:
- Olson, K., Unpublished report of The Dow Chemical Company (1960)
- Title:
- No information
- Author:
- Smyth
- Year:
- 1 969
- Bibliographic source:
- Smyth, H.F.Jr. et al., Am.Ind.Hyg.Assoc.J., 30(5), 470-476 (1969)
- Title:
- No information
- Author:
- OECD
- Year:
- 1 999
- Bibliographic source:
- OECD SIDS for glycidyl methacrylate, December 1999
Materials and methods
Test guideline
- Guideline:
- other: no data
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2,3-epoxypropyl methacrylate
- EC Number:
- 203-441-9
- EC Name:
- 2,3-epoxypropyl methacrylate
- Cas Number:
- 106-91-2
- Molecular formula:
- C7H10O3
- IUPAC Name:
- oxiran-2-ylmethyl methacrylate
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: albino
Test system
- Amount / concentration applied:
- Undiluted glycidyl methacrylate was directly instilled into the eye of rabbits
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Time point:
- other: 7 days
- Score:
- 4
- Max. score:
- 6
- Irritant / corrosive response data:
- Moderate to severe irritation and corneal damage was induced. Corneal damage did not heal within 7 days post-dosing. This ocular damage was prevented by washing with water within 30 seconds.
- Other effects:
- Not reported.
Applicant's summary and conclusion
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
