Registration Dossier

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Referenceopen allclose all

Title:
No information
Author:
Olson
Year:
1960
Bibliographic source:
Olson, K., Unpublished report of The Dow Chemical Company (1960)
Title:
No information
Author:
Smyth
Year:
1969
Bibliographic source:
Smyth, H.F.Jr. et al., Am.Ind.Hyg.Assoc.J., 30(5), 470-476 (1969)
Title:
No information
Author:
OECD
Year:
1999
Bibliographic source:
OECD SIDS for glycidyl methacrylate, December 1999

Materials and methods

Test guideline
Guideline:
other: no data
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2,3-epoxypropyl methacrylate
EC Number:
203-441-9
EC Name:
2,3-epoxypropyl methacrylate
Cas Number:
106-91-2
Molecular formula:
C7H10O3
IUPAC Name:
oxiran-2-ylmethyl methacrylate

Test animals / tissue source

Species:
rabbit
Strain:
other: albino

Test system

Amount / concentration applied:
Undiluted glycidyl methacrylate was directly instilled into the eye of rabbits

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Time point:
other: 7 days
Score:
4
Max. score:
6
Irritant / corrosive response data:
Moderate to severe irritation and corneal damage was induced. Corneal damage did not heal within 7 days post-dosing. This ocular damage was prevented by washing with water within 30 seconds.
Other effects:
Not reported.

Applicant's summary and conclusion