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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Referenceopen allclose all

Title:
No information
Author:
Nitschke
Year:
1990
Bibliographic source:
Nitschke, K. et al., Unpublished report of The Dow Chemical Company (acute inhalation) (1990)
Title:
No information
Author:
OECD
Year:
1999
Bibliographic source:
OECD SIDS for glycidyl methacrylate, December 1999

Materials and methods

Test guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2,3-epoxypropyl methacrylate
EC Number:
203-441-9
EC Name:
2,3-epoxypropyl methacrylate
Cas Number:
106-91-2
Molecular formula:
C7H10O3
IUPAC Name:
oxiran-2-ylmethyl methacrylate
Test material form:
other: liquid
Details on test material:
99.8% pure based on gas chromatography

Test animals

Species:
rat
Strain:
Fischer 344
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Analytical verification of test atmosphere concentrations:
yes
Duration of exposure:
4 h
Concentrations:
105 ppm (610 mg/m3), 269 ppm (1563 mg/m3), 412 ppm (2394 mg/m3).
412 ppm was the highest practically attainable vapour concentration.
No. of animals per sex per dose:
5 males and 5 females at each dose level

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC0
Effect level:
> 412 ppm
Exp. duration:
4 h
Mortality:
None
Clinical signs:
other: The highest concentration was the maximum practically attainable concentration and lower concentrations were run due to eye effects observed at higher concentrations. At nominal concentrations of 412 ppm (2,394 mg/m3) and 269 ppm (1,563 mg/m3), weight los

Applicant's summary and conclusion

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