2,3-epoxypropyl methacrylate

Endpoint summary

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion

Dose descriptor:

LD50

Value:

597 mg/kg bw

Acute toxicity: via dermal route

Endpoint conclusion

Dose descriptor:

LD50

Value:

480 mg/kg bw

Additional information

Acute toxicity

[SIDS data] Oral LD50 value for glycidyl methacrylate was 597 mg/kg b.w. for rat (Zdravko et al.: 1985). In inhalation toxicity study by OECD TG 403, there was no mortality observed in rats exposed for 4 hours at 2,394 mg/m3, the highest practically attainable vapor concentration. Change of respiration (labored breathing) and eyes (irritation and corneal opacity), and decrease in body weight were induced even at the lowest concentration of 1,563 mg/m3. (Nitschke et al.: 1990) Dermal LD50 for rabbits was 480 mg/kg b.w. (Smyth et al.: 1969).

In another inhalation toxicity study, acute exposure to rats with saturated vapour of this chemical resulted in a maximum survival time of 2 hours (Smyth et al.: 1969). It was reported that saturated vapour of glycidyl methacrylate at 20 °C was 474 ppm (2,754 mg/m3) (Draft Workplace Environmental Exposure Level Guide: 1999).

Routes              Strain              Type              Values                     Reference

Oral                     Rats              LD50              597 mg/kg              Zdravko, 1985

Rats              LD50              about 700 mg/kg     Olson, 1960; Smyth, 1969

Rats*            LD50              451 mg/kg               EPA/OTS, 1992

Mice             LD50              390 mg/kg               Zdravko, 1985

Mice             LD50              1050 mg/kg             Smyth, 1969

Guinea pigs   LD50              697 mg/kg               Zdravko, 1985

Inhalation             Rats              LC0               2394 mg/m3/4hr       Nitschke, 1990

                            Rats**         LCL0              1400 mg/m3/6hr       Haag, 1953

                            Rabbits**     LCL0              1400 mg/m3/6hr      Haag, 1953

                           Guinea pigs   LCL0              1400 mg/m3.6hr      Haag, 1953

Dogs             LCL0              1400 mg/m3/6hr      Haag, 1953

Dermal                Rabbits          LD50              480 mg/kg              Smyth, 1969

Intraperitoneal       Rats              LD50              290 mg/kg              Petrov, 1973

Mice              LD50              350 mg/kg              Petrov, 1973

* as a mixture of glycidyl methacrylate (97.8 %), epichlorohydrin (0.3 %) and dichlorohydrin (0.6 %)

** Changes in lungs, thorax, respiration, etc. were observed.

Justification for classification or non-classification

Based on the available data glycidyl methacrylate must be classified according to REACH and CLP as

Acute toxicity oral Category 4 (H302)

Acute toxicity dermal Category 3 (H311)

Specific Target Organ Toxicity, Single Exposure Category 1 (damage to the respiratory tract after inhalation) (H370)

Glycidyl methacrylate is classified under DSD as Xn;R20/21/22. However, the CLP classification is more accurate