Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 203-441-9 | CAS number: 106-91-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 597 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 480 mg/kg bw
Additional information
Acute toxicity
[SIDS data] Oral LD50 value for glycidyl methacrylate was 597 mg/kg b.w. for rat (Zdravko et al.: 1985). In inhalation toxicity study by OECD TG 403, there was no mortality observed in rats exposed for 4 hours at 2,394 mg/m3, the highest practically attainable vapor concentration. Change of respiration (labored breathing) and eyes (irritation and corneal opacity), and decrease in body weight were induced even at the lowest concentration of 1,563 mg/m3. (Nitschke et al.: 1990) Dermal LD50 for rabbits was 480 mg/kg b.w. (Smyth et al.: 1969).
In another inhalation toxicity study, acute exposure to rats with saturated vapour of this chemical resulted in a maximum survival time of 2 hours (Smyth et al.: 1969). It was reported that saturated vapour of glycidyl methacrylate at 20 °C was 474 ppm (2,754 mg/m3) (Draft Workplace Environmental Exposure Level Guide: 1999).
Routes Strain Type Values Reference
Oral Rats LD50 597 mg/kg Zdravko, 1985
Rats LD50 about 700 mg/kg Olson, 1960; Smyth, 1969
Rats* LD50 451 mg/kg EPA/OTS, 1992
Mice LD50 390 mg/kg Zdravko, 1985
Mice LD50 1050 mg/kg Smyth, 1969
Guinea pigs LD50 697 mg/kg Zdravko, 1985
Inhalation Rats LC0 2394 mg/m3/4hr Nitschke, 1990
Rats** LCL0 1400 mg/m3/6hr Haag, 1953
Rabbits** LCL0 1400 mg/m3/6hr Haag, 1953
Guinea pigs LCL0 1400 mg/m3.6hr Haag, 1953
Dogs LCL0 1400 mg/m3/6hr Haag, 1953
Dermal Rabbits LD50 480 mg/kg Smyth, 1969
Intraperitoneal Rats LD50 290 mg/kg Petrov, 1973
Mice LD50 350 mg/kg Petrov, 1973
* as a mixture of glycidyl methacrylate (97.8 %), epichlorohydrin (0.3 %) and dichlorohydrin (0.6 %)
** Changes in lungs, thorax, respiration, etc. were observed.
Justification for classification or non-classification
Based on the available data glycidyl methacrylate must be classified according to REACH and CLP as
Acute toxicity oral Category 4 (H302)
Acute toxicity dermal Category 3 (H311)
Specific Target Organ Toxicity, Single Exposure Category 1 (damage to the respiratory tract after inhalation) (H370)
Glycidyl methacrylate is classified under DSD as Xn;R20/21/22. However, the CLP classification is more accurate
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