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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Referenceopen allclose all

Title:
No information
Author:
Shi Tao et al.
Year:
1988
Bibliographic source:
Shi Tao et al., Zhongguo Yaolixue Yu Dulixue Zazhi, 2(3), 226-31 (1988).
Title:
No information
Author:
OECD
Year:
1999
Bibliographic source:
OECD SIDS for glycidyl methacrylate, December 1999

Materials and methods

GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2,3-epoxypropyl methacrylate
EC Number:
203-441-9
EC Name:
2,3-epoxypropyl methacrylate
Cas Number:
106-91-2
Molecular formula:
C7H10O3
IUPAC Name:
oxiran-2-ylmethyl methacrylate

Test animals

Species:
rabbit

Administration / exposure

Route of administration:
other: intra-venous and subcutaneous
Doses / concentrations
Remarks:
Doses / Concentrations:
intravenous: 200 mg/kg
subcutaneous: 800 mg/kg

Results and discussion

Any other information on results incl. tables

Toxicokinetics of glycidyl methacrylate was investigated in rabbits. After an intravenous injection at 200 mg/kg, the concentration-time curve of this chemical could exactly fit the two-compartment open model, and over 95 % of the parent compound had disappeared from the blood within 10 minutes. Following a subcutaneous injection at 800 mg/kg, the toxicokinetics appeared to fit a first-order absorption one-compartment open model. This chemical was metabolized by a first-order process in incubation with whole blood, plasma, erythrocyte suspension, and homogenates of brain, heart, liver, lung, spleen, kidney, small intestine, and muscle. The highest rate of elimination had been found in blood and liver homogenate. The subcutaneous co-administration of tri-o-cresyl-phosphate (an carboxylesterase inhibitor) with this chemical resulted in about a ten­fold increase in the maximum blood concentrations of this chemical, compared to those of animals dosed with this chemical alone. In vitro,elimination rate could be also decreased by tri-o-cresyl

phosphate.

Applicant's summary and conclusion

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