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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Additional information


Fischer 344 rats were exposed by inhalation to glycidyl methacrylate at approximately 0.5, 2 or 15 ppm (2.9, 12, 87 mg/m3), 6 hours/day, 5 days/ week for 13weeks (calculated daily dose: 0.35, 1.46, 10.59 mg/kg/day). At week 4, there was a low incidence of rat with nasal discharge and enlarged nostrils at 2 and 15 ppm. There were no other treatment-related effects. A functional observation battery (FOB) and motor activity (MA) were conducted preexposure and at the end of each month of exposure. In addition, the postexposure neurotoxicity evaluation focused on evoked potential testing of the visual (FEP), auditory (ABR), somatosensory system (SEP), and caudal nerves (CNAP), and a comprehensive neuropathological examination.

There was no evidence of neurotoxic effects at any exposure level. (Mattsson et al.: 1996)

Justification for classification or non-classification

Based on the available studies classification under REACH and CLP of glycidyl methacrylate is not required.