Registration Dossier
Registration Dossier
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EC number: 203-441-9 | CAS number: 106-91-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
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- Auto flammability
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- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
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- Nanomaterial aspect ratio / shape
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- Nanomaterial surface chemistry
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- Endpoint summary
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- Environmental data
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
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- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
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- Specific investigations
- Exposure related observations in humans
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- Additional toxicological data
Neurotoxicity
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
Neurotoxicity
Fischer 344 rats were exposed by inhalation to glycidyl methacrylate at approximately 0.5, 2 or 15 ppm (2.9, 12, 87 mg/m3), 6 hours/day, 5 days/ week for 13weeks (calculated daily dose: 0.35, 1.46, 10.59 mg/kg/day). At week 4, there was a low incidence of rat with nasal discharge and enlarged nostrils at 2 and 15 ppm. There were no other treatment-related effects. A functional observation battery (FOB) and motor activity (MA) were conducted preexposure and at the end of each month of exposure. In addition, the postexposure neurotoxicity evaluation focused on evoked potential testing of the visual (FEP), auditory (ABR), somatosensory system (SEP), and caudal nerves (CNAP), and a comprehensive neuropathological examination.
There was no evidence of neurotoxic effects at any exposure level. (Mattsson et al.: 1996)
Justification for classification or non-classification
Based on the available studies classification under REACH and CLP of glycidyl methacrylate is not required.
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