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Toxicological information

Repeated dose toxicity: other routes

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Administrative data

Endpoint:
repeated dose toxicity: other route
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well-documented study report which meets basic scientific principles

Data source

Reference
Title:
No information
Author:
Reustle, J.A. and Scribner, H.E. (1979): o-Dichlorobenzene;|Myelotoxicity and cytogenetic study in rats. Report of the|Toxicology Department, Rohm and Haas Company, Spring House,|Pennsylvania. EPA/OTS Doc. No. 878212182, 1-71

Materials and methods

GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2-dichlorobenzene
EC Number:
202-425-9
EC Name:
1,2-dichlorobenzene
Cas Number:
95-50-1
Molecular formula:
C6H4Cl2
IUPAC Name:
1,2-dichlorobenzene

Test animals

Species:
rat
Strain:
other: COBS-CD (SD) Br
Sex:
male

Administration / exposure

Route of administration:
subcutaneous
Duration of treatment / exposure:
16 d
Frequency of treatment:
daily
Doses / concentrations
Remarks:
Doses / Concentrations:
40, 200 or 1000 mg/kg bw/d
Details on study design:
Post-exposure period: no

Results and discussion

Effect levels

Dose descriptor:
NOAEL
Effect level:
40 mg/kg bw/day
Sex:
male

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

All dose levels: no myelotoxic or cytogenetic effects (no significant chromosomal damage to bone marrow cells observable).
200 and 1000 mg/kg bw/d: significant increases in relative liver weights.
1000 mg/kg bw/d: increased mortality and decreased body weight gain.

Applicant's summary and conclusion

Conclusions:
All dose levels: no myelotoxic or cytogenetic effects (no significant chromosomal damage to bone marrow cells observable). 200 and 1000 mg/kg bw/d: significant increases in relative liver weights. 1000 mg/kg bw/d: increased mortality and decreased body weight gain.
Executive summary:

All dose levels: no myelotoxic or cytogenetic effects (no significant chromosomal damage to bone marrow cells observable).
200 and 1000 mg/kg bw/d: significant increases in relative liver weights.
1000 mg/kg bw/d: increased mortality and decreased body weight gain.