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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: other routes

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Administrative data

Endpoint:
repeated dose toxicity: other route
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well-documented study report which meets basic scientific principles

Data source

Reference
Title:
No information
Author:
Reustle, J.A. and Scribner, H.E. (1979): o-Dichlorobenzene;|Myelotoxicity and cytogenetic study in rats. Report of the|Toxicology Department, Rohm and Haas Company, Spring House,|Pennsylvania. EPA/OTS Doc. No. 878212182, 1-71

Materials and methods

GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2-dichlorobenzene
EC Number:
202-425-9
EC Name:
1,2-dichlorobenzene
Cas Number:
95-50-1
Molecular formula:
C6H4Cl2
IUPAC Name:
1,2-dichlorobenzene

Test animals

Species:
rat
Strain:
other: COBS-CD (SD) Br
Sex:
male

Administration / exposure

Route of administration:
subcutaneous
Duration of treatment / exposure:
16 d
Frequency of treatment:
daily
Doses / concentrations
Remarks:
Doses / Concentrations:
40, 200 or 1000 mg/kg bw/d
Details on study design:
Post-exposure period: no

Results and discussion

Effect levels

Dose descriptor:
NOAEL
Effect level:
40 mg/kg bw/day
Sex:
male

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

All dose levels: no myelotoxic or cytogenetic effects (no significant chromosomal damage to bone marrow cells observable).
200 and 1000 mg/kg bw/d: significant increases in relative liver weights.
1000 mg/kg bw/d: increased mortality and decreased body weight gain.

Applicant's summary and conclusion

Conclusions:
All dose levels: no myelotoxic or cytogenetic effects (no significant chromosomal damage to bone marrow cells observable). 200 and 1000 mg/kg bw/d: significant increases in relative liver weights. 1000 mg/kg bw/d: increased mortality and decreased body weight gain.
Executive summary:

All dose levels: no myelotoxic or cytogenetic effects (no significant chromosomal damage to bone marrow cells observable).
200 and 1000 mg/kg bw/d: significant increases in relative liver weights.
1000 mg/kg bw/d: increased mortality and decreased body weight gain.