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Diss Factsheets

Administrative data

Endpoint:
respiratory sensitisation: in vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Original reference not translated (Russian)

Data source

Reference
Title:
No information
Author:
Shmuter, L.M. and Genes, V.S.: in Issues of experimental|and clinical pathology. (ed. T.V. Mitin). L vov; L vov|Medical Institute, 1980: IV 135-136: cited in Chloroben-|zenes (Series "Scientific Reviews of Soviet Literature of|Toxicity and Hazards of Chemicals"), edited by Izmerov,|N.F., Centre for International Projects, GKNT, Moscow, 1988;|data compiled by Vasilenko, N.M. and Semiletkina, N.N.|(number of issue: 108)

Materials and methods

Principles of method if other than guideline:
Rabbits were exposed via inhalation to o-dichlorobenzene at a concentration of 0.05 mg/l for 7 months (5 days a week, 4 hours daily).
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2-dichlorobenzene
EC Number:
202-425-9
EC Name:
1,2-dichlorobenzene
Cas Number:
95-50-1
Molecular formula:
C6H4Cl2
IUPAC Name:
1,2-dichlorobenzene

Test animals

Species:
rabbit

Test system

Route of induction exposure:
inhalation

Results and discussion

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
Sensitization became obvious at early stages of poisoning in the absence of any pointers to systemic toxic action; as the signs of intoxication developed, allergic tests became negative but again took on a positive value closer to the cessation of experiment; o-dichlorobenzene triggered the production of antibodies to erythrocyte lysate and of antitissue antibodies to autoantigenes from the renal tissue (no further data).
Executive summary:

Sensitization became obvious at early stages of poisoning in the absence of any pointers to systemic toxic action; as the signs of intoxication developed, allergic tests became negative but again took on a positive value closer to the cessation of experiment; o-dichlorobenzene triggered the production of antibodies to erythrocyte lysate and of antitissue antibodies to autoantigenes from the renal tissue (no further data).