Registration Dossier
Registration Dossier
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EC number: 202-425-9 | CAS number: 95-50-1
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Original reference not translated
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- unknown
- Author:
- Bonnet P et al.
- Year:
- 1 979
- Bibliographic source:
- Archives des maladies professionnelles, de medecine du travail et de Securite Sociale (Paris) 40,805-810
- Reference Type:
- publication
- Title:
- unknown
- Author:
- Bonnet P et al.
- Year:
- 1 982
- Bibliographic source:
- Archives des maladies professionnelles, de medecine du travail et de Securite Sociale (Paris), 43, 261-265 (1982)
Materials and methods
- Principles of method if other than guideline:
- An acute toxicity study had been conducted on female mice. The LC50 was determined after inhalative exposure. The concentrations of the vaporised 1,2-dichlorobenzene were analysed regularly. The LC50 of 1,2-Dichlorobenzene was determinated in mice after 6 hour exposure.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- 1,2-dichlorobenzene
- EC Number:
- 202-425-9
- EC Name:
- 1,2-dichlorobenzene
- Cas Number:
- 95-50-1
- Molecular formula:
- C6H4Cl2
- IUPAC Name:
- 1,2-dichlorobenzene
- Details on test material:
- - Analytical purity: 99 %
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: OF1
- Sex:
- female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 6 h
- Concentrations:
- 1201-1279 ppm
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- 1 236 ppm
- Exp. duration:
- 6 h
Any other information on results incl. tables
LC50 = ca. 7.56 mg/L
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Executive summary:
Bonnet, 1979
An acute toxicity study had been conducted on female mice. The reliablility is not assignable because the publication is not translated. The LC50 was determined by inhalative exposure of female OF1 mice for 6 h. The concentrations (1201 - 1279 ppm) of the vaporised 1,2-dichlorobenzene were analysed regularly. A LC50 of 1236 ppm (7.55 mg/L) was stated. After conversion, the LC50 for 4h was 1854 ppm which results in an EU-GHS classification "Toxicity Category IV".
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