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Toxicological information

Dermal absorption

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Administrative data

Endpoint:
dermal absorption in vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Does not meet important criteria of today standard methods (no excreta sampling, blood sampling only at the end of the study, skin from application site not sampled, application area too small, exposure period too short)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1995

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 427 (Skin Absorption: In Vivo Method)
Deviations:
yes
Remarks:
; no excreta sampling, blood sampling only at the end of the study, skin from application site not sampled, application area too small, exposure period too short
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2-dichlorobenzene
EC Number:
202-425-9
EC Name:
1,2-dichlorobenzene
Cas Number:
95-50-1
Molecular formula:
C6H4Cl2
IUPAC Name:
1,2-dichlorobenzene
Details on test material:
Endpoint study record was created to contribute to teh overall remarks.

Test animals

Species:
rat
Details on test animals or test system and environmental conditions:
Endpoint study record was created to contribute to teh overall remarks.

Administration / exposure

Duration of exposure:
Endpoint study record was created to contribute to the overall remarks.
Doses:
Endpoint study record was created to contribute to the overall remarks.
No. of animals per group:
Endpoint study record was created to contribute to the overall remarks.
Details on study design:
Endpoint study record was created to contribute to teh overall remarks.
Details on in vitro test system (if applicable):
Endpoint study record was created to contribute to teh overall remarks.

Results and discussion

Absorption in different matrices:
Endpoint study record was created to contribute to teh overall remarks.
Total recovery:
Endpoint study record was created to contribute to teh overall remarks.
Conversion factor human vs. animal skin:
Endpoint study record was created to contribute to teh overall remarks.

Any other information on results incl. tables

Blood concentration increased quickly to a max. at 45min; minimal inflammation at 1h

Applicant's summary and conclusion