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Toxicological information

Repeated dose toxicity: dermal

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Administrative data

Endpoint:
short-term repeated dose toxicity: dermal
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: does not meet important criteria for today standard methods and insufficiently reported

Data source

Reference
Title:
No information
Author:
Morse, D.L. et al.: Clin. Toxicol. 15, 13-21 (1979)

Materials and methods

GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2-dichlorobenzene
EC Number:
202-425-9
EC Name:
1,2-dichlorobenzene
Cas Number:
95-50-1
Molecular formula:
C6H4Cl2
IUPAC Name:
1,2-dichlorobenzene
Details on test material:
undiluted o-dichlorobenzene (no further data)

Test animals

Species:
rabbit
Strain:
other: New Zealand (no further data)
Sex:
female

Administration / exposure

Details on exposure:
Route of Administration: dermal
Duration of treatment / exposure:
5 d
Frequency of treatment:
daily
Doses / concentrations
Remarks:
Doses / Concentrations:
0.1 ml/animal/d
Basis:

Control animals:
yes
Details on study design:
Post-exposure period: 12 d

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

o-dichlorobenzene had no chloracnegenic properties; no systemic toxic effects were noted in the rabbits; the microscopic examination of the rabbit livers showed no abnormalities.

Applicant's summary and conclusion