Registration Dossier
Registration Dossier
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EC number: 202-425-9 | CAS number: 95-50-1
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: does not meet important criteria for today standard methods and insufficiently reported
Data source
Reference
- Title:
- No information
- Author:
- Morse, D.L. et al.: Clin. Toxicol. 15, 13-21 (1979)
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,2-dichlorobenzene
- EC Number:
- 202-425-9
- EC Name:
- 1,2-dichlorobenzene
- Cas Number:
- 95-50-1
- Molecular formula:
- C6H4Cl2
- IUPAC Name:
- 1,2-dichlorobenzene
- Details on test material:
- undiluted o-dichlorobenzene (no further data)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: New Zealand (no further data)
- Sex:
- female
Administration / exposure
- Details on exposure:
- Route of Administration: dermal
- Duration of treatment / exposure:
- 5 d
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.1 ml/animal/d
Basis:
- Control animals:
- yes
- Details on study design:
- Post-exposure period: 12 d
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
o-dichlorobenzene had no chloracnegenic properties; no systemic toxic effects were noted in the rabbits; the microscopic examination of the rabbit livers showed no abnormalities.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
