Registration Dossier
Registration Dossier
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EC number: 202-425-9 | CAS number: 95-50-1
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: does not meet important criteria for today standard methods and insufficiently reported
Data source
Reference
- Title:
- No information
- Author:
- Morse, D.L. et al.: Clin. Toxicol. 15, 13-21 (1979)
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,2-dichlorobenzene
- EC Number:
- 202-425-9
- EC Name:
- 1,2-dichlorobenzene
- Cas Number:
- 95-50-1
- Molecular formula:
- C6H4Cl2
- IUPAC Name:
- 1,2-dichlorobenzene
- Details on test material:
- undiluted o-dichlorobenzene (no further data)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: New Zealand (no further data)
- Sex:
- female
Administration / exposure
- Details on exposure:
- Route of Administration: dermal
- Duration of treatment / exposure:
- 5 d
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.1 ml/animal/d
Basis:
- Control animals:
- yes
- Details on study design:
- Post-exposure period: 12 d
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
o-dichlorobenzene had no chloracnegenic properties; no systemic toxic effects were noted in the rabbits; the microscopic examination of the rabbit livers showed no abnormalities.
Applicant's summary and conclusion
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