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Water solubility

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water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data given
no guideline followed
Principles of method if other than guideline:
The experiment was conducted in sealed stainless steel centrifuge tubes. An excess of the compound was added to a tube containing distilled water, and the tube was sealed and allowed to equilibriate at 25°C with constant or intermittent shaking. Equilibration was generally complete within 1 week. The mixture was then centrifuged at 10 000 rpm for 60 min in a head preequilibriated to 25°C, following which aliquots of the solution were removed for analysis either with a pipet or, for more volatile compounds such as chloroform, with a syringe. The entire procedure was carried out at least twice and each analysis was also conducted in duplicate. The substance was analysed with LSC (liquid scintillation counting).
GLP compliance:
Type of method:
flask method
Water solubility:
ca. 155.8 mg/L
25 °C
Remarks on result:
other: pH not reported
Interpretation of results: moderately soluble (100-1000 mg/L)
The water solubility of the substance was determined to be 155.8 mg/L at 25°C.
Executive summary:

The water solubility of the substance was determined via flask method to be 155.8 mg/L at 25°C.

Description of key information

The water solubility of the substance was determined to be 155.8 mg/L at 25°C.

Key value for chemical safety assessment

Water solubility:
155.8 mg/L
at the temperature of:
25 °C

Additional information

There are several valid results available for the water solubility of the substance. As worst case the highest value was taken as key study.