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EC number: 248-953-3 | CAS number: 28305-25-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No long-term toxicity data are available for the toxicity of calcium lactate to fish. However, a waiver is applied for this endpoint.
Key value for chemical safety assessment
Additional information
Calcium lactate fully dissociates into Ca2+ ions and lactate. The ecotoxicology of calcium lactate can be understood in terms of the ecotoxicology of calcium chloride and lactic acid.
Calcium chloride is not toxic in short-term toxicity tests with fish at concentrations far above 100 mg/L, the limit concentration, showing that Ca2+ is not toxic to aquatic organisms. Lactic acid shows slight effects at 56 mg/L in a short-term toxicity test with rainbow trout, while the LC50 was 130 mg/L. However, it should be noted that all observed effects are due to the low pH induced by high concentrations of lactic acid, and will completely disappear at lower concentrations. This is also evident from available aquatic toxicity studies to Daphnia with sodium lactate, which has a LC50 of > 6 g/L (>53.5 mM) and (acute) NOEC of 6 g/L (compare with acute daphnia LC50 for lactic acid is 130 mg/L (1.44 mM)). When comparing toxicity expressed in molar concentrations, toxicity to Daphnia was >37 times lower for sodium lactate compared to lactic acid (>53.5/1.44 = >37). Therefore toxicity of lactate, be it in the form of sodium lactate or calcium lactate, to fish is expected to be much lower than for lactic acid as well. Moreover, relevant chronic toxicity is not expected from a substance that is an essential part of primary biochemical processes.
Testing is waived since it is shown highly unlikely that adverse effects of calcium lactate occur in short-term toxicity test with fish at concentration up to 100 mg/L, the limit concentration. Further, calcium lactate is readily biodegradable (see section 5.2.1) and as a consequence, no chronic exposure of fish is expected.
Therefore, and for reasons of animal welfare, a long-term toxicity study in fish is not provided.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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