Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 248-953-3 | CAS number: 28305-25-1
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Calcium lactate fully dissociates into Ca2+ ions and lactate. The ecotoxicology of calcium lactate can be understood in terms of the ecotoxicology of calcium chloride and lactic acid.
The lowest 96-hour LC50 value for calcium chloride of 4630 mg/L is from a study with fathead minnow (Pimephales promelas) conducted under EPA guideline.
The 96-hour LC50 value of 130 mg/L for lactic acid was determined in a static exposure system with rainbow trout (Oncorhynchus mykiss). However, it should be noted that all observed effects are due to the low pH induced by high concentrations of lactic acid, and will completely disappear at lower concentrations.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 157 mg/L
Additional information
Calcium lactate fully dissociates into Ca2+ ions and lactate. The ecotoxicology of calcium lactate can be understood in terms of the ecotoxicology of calcium chloride and lactic acid.
Calcium chloride:
Several studies on acute toxicity to fish have been reported. The lowest 96-hour LC50 value of 4630 mg/L is from a study with fathead minnow (Pimephales promelas) conducted under EPA guideline. Furthermore, there are two studies with bluegill sunfish (Lepomis macrochirus) from Cairns and Scheier (1959) and Trama (1954) and a study with mosquitofish (Gambusia affinis) from Wallen et al. (1957) in which 96-hour LC50¬ values between 9500 and 13400 mg/L were determined.
Lactic acid:
Three short term toxicity studies with lactic acid with fish are available. The 96-hour LC50 value of 130 mg/L for lactic acid was determined in a static exposure system with rainbow trout (Oncorhynchus mykiss). However, it should be noted that all observed effects are due to the low pH induced by high concentrations of lactic acid, and will completely disappear at lower concentrations. This is also evident from available aquatic toxicity studies with sodium lactate, which has a daphnia LC50 of > 6 g/L and (acute) NOEC of 6 g/L (compare with daphnia LC50 for lactic acid of 130 mg/L).
Calcium lactate:
The molar ratio to convert from lactic acid by weight to sodium lactate by weight is 1.21, which gives an estimate for the 96h-LC50 for fish of 157 mg/L. Given that effects of lactic acid can be attributed to pH effects and the neutral pH of calcium lactate solutions, the derived LC50 should be regarded as an extreme overestimation of the toxicity of calcium lactate.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
