Calcium (S)-2-hydroxypropionate

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2013-01-15 to 2013-03-18

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

static method

Specific details on test material used for the study:

- Test substance: Puracal PP/USP
- CAS number: 28305-25-1
- EC number: 248-953-3
- Batch no.: 1107003133
- Purity: 73-95%
- Apprearance: White powder
- Retest date: 2016-07-29

Key result

Test no.:

#1

Temp.:

20 °C

Vapour pressure:

< 75 Pa

Remarks on result:

other: The sample couldn't be degassed satisfactorily. The determined vapour pressure can most likely be assigned to trapped volatiles.

Table 1: Test results

Full test results
Temp [°C]	Pressure [mbar]
Run 1
20 (calculated)	0.75
38.4	5.7
40.5	6.3
30.6	2.4
42.8	7.9
47	11.5
50.0	17.1
52.2	21.4
55.1	26
Run 2
20 (calculated)	1.45
33.3	5
36.9	7.8
42.4	13
46.9	17.9
49.4	21.9
51.9	27.1
53.9	32.2

 

 

Comments on Run 1:

Sample was degassed over a period of 30 hours. Fluctuations in pressure were seen during degassing, this is a characteristic of trapped gasses within the sample. The vacuum within the apparatus was taken down to -0.046 mbar where the pressure appeared to decrease no further. Normally the vacuum would be taken below 0.01 mbar and often below 0.006 mbar to ensure full degassing. The result obtained was higher than expected for a material of the nature of the sample.

 

Comments on Run 2:

Sample was degassed over a period of 32 hours. Fluctuations in pressure were seen during degassing, this is a characteristic of trapped gasses within the sample. The vacuum within the apparatus was taken down to -0.045 mbar where the pressure appeared to decrease no further. Normally the vacuum would be taken below 0.01 mbar and often below 0.006 mbar to ensure full degassing. The result obtained was much higher than expected for a material of the nature of the sample.

 

Overall Comments:

The readings taken during test run 1 and 2 were found to differ greatly. The extrapolated results were higher than expected for a substance such as this. It was suspected that there were trapped gasses that were not being removed despite prolonged degassing and these were producing high readings. After consultation with the sponsor, the result has been reported as <75 Pa.

Conclusions:

The vapour pressure was determined to be < 75 Pa at 20 °C.

Executive summary:

In a GLP study conducted according EU Method A.4, the vapour pressure of calcium (S)-lactate was determined by using the static method. The vapour pressure was dertiermined to be < 75 Pa at 20 °C.

Description of key information

In a GLP study conducted according EU Method A.4, the vapour pressure of Calcium (S)-lactate was determined by using the static method. The vapour pressure was determined to be < 75 Pa at 20 °C.

Key value for chemical safety assessment

Vapour pressure:

75 Pa

at the temperature of:

20 °C