Registration Dossier
Registration Dossier
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EC number: 204-709-8 | CAS number: 124-68-5
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The pKa values were determined by potentiometric titration with 0.5 N Hydrochloric acid.
- GLP compliance:
- no
- Specific details on test material used for the study:
- two test items:
AMP-95 = industrial grade, contains some secondary amines
AMP Ultra PC 2000 = high-purity grade, <0.5% secondary amines - Dissociating properties:
- yes
- pKa:
- 9.74
- Temp.:
- 25 °C
- Remarks on result:
- other: AMP-95 (industrial grade)
- pKa:
- 9.7
- Temp.:
- 25 °C
- Remarks on result:
- other: AMP Ultra PC 2000 (high-purity grade)
- Conclusions:
- At 25°C, the pKa for AMP Ultra PC 2000 (high-purity grade) was 9.70 and the pKa for AMP-95 (industrial grade) was 9.74. The slight difference is explained by the higher secondary amine content of the latter.
Reference
Description of key information
At 25°C, the pKa for AMP Ultra PC 2000 (high-purity grade) was 9.70 and the pKa for AMP-95 (industrial grade) was 9.74. The slight difference is explained by the higher secondary amine content of the latter.
Studies from the 1990's confirm similar values.
Key value for chemical safety assessment
- pKa at 20°C:
- 9.7
Additional information
Wort-case value correspodning to an industrial grade. High-purity grades show a lower pKa (9.70).
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