Registration Dossier

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
Not applicable
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: documentation insufficient for assessment
Cross-reference
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report date:
1976

Materials and methods

GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-amino-2-methylpropanol
EC Number:
204-709-8
EC Name:
2-amino-2-methylpropanol
Cas Number:
124-68-5
Molecular formula:
C4H11NO
IUPAC Name:
2-amino-2-methylpropan-1-ol
Details on test material:
- Name of test material (as cited in study report): AMP; P-1826
- Lot/batch No.: C450511

Test animals

Species:
mouse
Strain:
not specified
Sex:
female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Doses:
460, 300, 220, 180, 160 mg/kg
No. of animals per sex per dose:
Ten
Control animals:
no

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
230 mg/kg bw
Remarks on result:
other: ±25

Any other information on results incl. tables

Not applicable

Applicant's summary and conclusion

Conclusions:
The i.p. LD50 for female mice was 230±25 mg/kg.