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Environmental fate & pathways

Biodegradation in soil

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Administrative data

Endpoint:
biodegradation in soil, other
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1989
Report date:
1989
Reference Type:
study report
Title:
Unnamed
Year:
1992

Materials and methods

Principles of method if other than guideline:
lab's own protocol, see methods
GLP compliance:
no
Test type:
laboratory

Test material

Constituent 1
Chemical structure
Reference substance name:
2-amino-2-methylpropanol
EC Number:
204-709-8
EC Name:
2-amino-2-methylpropanol
Cas Number:
124-68-5
Molecular formula:
C4H11NO
IUPAC Name:
2-amino-2-methylpropan-1-ol
Specific details on test material used for the study:
AMP-90
Radiolabelling:
yes

Study design

Oxygen conditions:
aerobic/anaerobic

Results and discussion

Material (mass) balanceopen allclose all
Sampling day(s):
30 d
% Total extractable:
>= 3.8 - <= 4.9
% Non extractable:
>= 18.4 - <= 31.4
% CO2:
>= 47.6 - <= 52.9
Remarks on result:
other: aerobic conditions, sampling time 30-35 days, range over 4 replicates, recovery 82.2-96.6%, liquid portion 0.2-0.5%
Sampling day(s):
30 d
% Total extractable:
>= 11.7 - <= 13.1
% Non extractable:
>= 10.9 - <= 20.7
% CO2:
>= 13 - <= 16.3
Remarks on result:
other: anaerobic conditions, sampling time 30-35 days, range over 4 replicates, recovery 88.7-95.1%, liquid portion 0.2% in all replicates
% Degradationopen allclose all
Key result
% Degr.:
50
Parameter:
CO2 evolution
Sampling time:
30 d
Remarks on result:
other: aerobic conditions, timepoint is 30-35 days, mean degradation to CO2 over 4 replicates
Key result
% Degr.:
15
Parameter:
CO2 evolution
Sampling time:
30 d
Remarks on result:
other: anaerobic conditions, timepoint is 30-35 days, mean degradation to CO2 over 4 replicates
Half-life / dissipation time of parent compound
DT50:
30 - 35 d
Type:
not specified
Remarks on result:
other: aerobic conditions. estimate based on mass balance results showing 50% degradation to CO2, DT50 was not calculated in report
Transformation products:
not specified
Remarks:
the "non extractable" portion of the mass balance may correspond to bound AMP, hence metabolites. A study in houseflies (see IUCLID section 6.5) evidenced incorporation into phospholipids instead of choline, and this may also exist in soil organisms.

Applicant's summary and conclusion

Conclusions:
In a soil degradation study in aerobic and anaerobic conditions, AMP-90 was degraded to CO2 by 50% and 15%, resp., over 30-35 days. This evidences that AMP degrades in soil and thta is has no toxicity to soil micro-organisms. The % non-extractable may suggest some metabolism in soil organisms.