2-amino-2-methylpropanol

Biodegradation in soil

Administrative data

Endpoint:

biodegradation in soil, other

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

1989

Report date:

1989

Reference 2

Reference Type:

study report

Title:

Unnamed

Year:

1992

Materials and methods

Principles of method if other than guideline:

lab's own protocol, see methods

GLP compliance:

no

Test type:

laboratory

Test material

Test material information

Constituent 1

Reference substance name:

2-amino-2-methylpropanol

EC Number:

204-709-8

EC Name:

2-amino-2-methylpropanol

Cas Number:

124-68-5

Molecular formula:

C4H11NO

IUPAC Name:

2-amino-2-methylpropan-1-ol

Specific details on test material used for the study:

AMP-90

Radiolabelling:

yes

Study design

Oxygen conditions:

aerobic/anaerobic

Results and discussion

Material (mass) balance

Material (mass) balance 1

Sampling day(s):

30 d

% Total extractable:

>= 3.8 - <= 4.9

% Non extractable:

>= 18.4 - <= 31.4

% CO2:

>= 47.6 - <= 52.9

Remarks on result:

other: aerobic conditions, sampling time 30-35 days, range over 4 replicates, recovery 82.2-96.6%, liquid portion 0.2-0.5%

Material (mass) balance 2

Sampling day(s):

30 d

% Total extractable:

>= 11.7 - <= 13.1

% Non extractable:

>= 10.9 - <= 20.7

% CO2:

>= 13 - <= 16.3

Remarks on result:

other: anaerobic conditions, sampling time 30-35 days, range over 4 replicates, recovery 88.7-95.1%, liquid portion 0.2% in all replicates

% Degradation

% Degradation 1

Key result

% Degr.:

50

Parameter:

CO2 evolution

Sampling time:

30 d

Remarks on result:

other: aerobic conditions, timepoint is 30-35 days, mean degradation to CO2 over 4 replicates

% Degradation 2

Key result

% Degr.:

15

Parameter:

CO2 evolution

Sampling time:

30 d

Remarks on result:

other: anaerobic conditions, timepoint is 30-35 days, mean degradation to CO2 over 4 replicates

Half-life / dissipation time of parent compound

DT50:

30 - 35 d

Type:

not specified

Remarks on result:

other: aerobic conditions. estimate based on mass balance results showing 50% degradation to CO2, DT50 was not calculated in report

Transformation products:

not specified

Remarks:

the "non extractable" portion of the mass balance may correspond to bound AMP, hence metabolites. A study in houseflies (see IUCLID section 6.5) evidenced incorporation into phospholipids instead of choline, and this may also exist in soil organisms.

Applicant's summary and conclusion

Conclusions:

In a soil degradation study in aerobic and anaerobic conditions, AMP-90 was degraded to CO2 by 50% and 15%, resp., over 30-35 days. This evidences that AMP degrades in soil and thta is has no toxicity to soil micro-organisms. The % non-extractable may suggest some metabolism in soil organisms.