Registration Dossier

Administrative data

Endpoint:
biotransformation and kinetics
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The research paper presents endpoints not subject to guidelines, but are well documented.

Data source

Reference
Reference Type:
publication
Title:
The Incorporation of 1-aminobutanols into the Phospholipids of Housefly (Musca domestica) Larvae
Author:
Bridges, R.G. and Ricketts, J.
Year:
1965
Bibliographic source:
J. Insect Physiol. 11: 225

Materials and methods

Principles of method if other than guideline:
Larvae were grown in diets with and without choline, and growth rate and mortality were observed.
GLP compliance:
not specified
Type of medium:
other: Musca domestica

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Obtained commercially and where necessary redistilled before use.

Results and discussion

Transformation products:
yes

Any other information on results incl. tables

 

When no choline is included in the diet, growth retardation is noted. The test material in the diet causes death of the larvae before the sixth day after hatching. If choline chloride is added to the diet with the test material, growth is normal.

Decreasing the level of choline in the diet causes an increase by 7-24% (of total lipids) in the proportion of phosphatidyl-aminobutanols found in larval lipids.

Applicant's summary and conclusion

Conclusions:
When no choline is included in the diet, growth retardation is noted. The test material in the diet causes death of the larvae before the sixth day after hatching. If choline chloride is added to the diet with the test material, growth is normal.