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EC number: 204-709-8 | CAS number: 124-68-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
3 Skin irritation studies (one with multiple exposures), 2 Eye irritation studies. All in vivo.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin:
In a study following a protocol similar to the Draize test AMP was tested for irritation using an occluded application to the shaved backs of 6 rabbits (DR-0309-4391-012). The reporting of the study is limited, but under the circumstances of the study AMP was found to be highly irritating, producing clear signs of erythema and odema. There was no information on the recovery period or reversibility of the lesions. In a second study (DR-0309-4391-016) a single rabbit was used to confirm AMP was not corrosive. The test material was applied undiluted to the shaved back of a single rabbit under an occlusive dressing. After 4 hours the patch was removed and the skin was scored for corrosivity. The conclusion of the study was that AMP is not corrosive. The study was terminated at 4 hours and so no details on recovery were reported. Finally, a 5-day repeated dose dermal study was conducted in rabbits (Machle et al., 1940). There are minimal details available in this report and information relating to animal numbers, dose applied, and other key experimental parameters are missing. However the study confirmed that AMP was irritating under the circumstances of the study.
In a study to assess the irritancy to skin, AMP diluted at 4.75% in water was applied to the skin of 6 rabbits. None of the rabbits showed any sign of skin irritation (Parekh, 1980: scores of 0 at all time-points). This study is used as a basis for a specific concentration limit of 5% for Skin Irritation 2. This is very conservative given that no irritation was noted just below this concentration.
Eyes:
In a study designed to assess the irritancy to eyes, AMP was applied to the eyes of 12 rabbits undiluted. In six of the rabbits, the AMP was washed out 15-30 seconds after dosing. In this study AMP caused serious damage to the eyes and ultimately destroyed the vision (Power, 1975b). The damage was not mitigated even with an immediate flushing of the eyes. The serious occular damage is likely the result of the high pH of the compound instead of any inherent toxicity based on the chemical structure.
In a study to assess the irritancy to eyes, AMP diluted at 4.75% in water was applied to the eyes of 9 rabbits. None of the rabbits showed any sign of eye irritation (Parekh, 1980: scores of 0 at all time-points). This study is used as a basis for specific concentration limits of 5% for Eye Irritation 2, and 10% for Eye Damage 1 (as pure AMP warrants Eye Damage 1). The cut-off of 10% is considered conservative.
Respiratory Tract:
Studies of the potential irritant characteristics of inhaled AMP have been undertaken using the ATSM E981 sensory irritation methodology. Restrained mice were head-only exposed up to 1160 mg/m3 aerosolized AMP for 3 hours followed by a 20 minute recovery period (Detwiler-Okabayashi and Shaper, 1996). No deaths were recorded but sensory and pulmonary irritation of mice was noted
Effects on skin irritation/corrosion: irritating
Effects on eye irritation: corrosive
Effects on respiratory irritation: irritating
Justification for classification or non-classification
Based on the above data and in accordance with Annex 1 to the Dangerous substances directive, AMP is classified as
- Skin Irritation 2, with a specific concentration limit of 5% for Skin Irritation 2, based on absence of any skin irritation at 4.75%.
- Eye Damage 1, with specific concentration limits of 5% for Eye Irritation 2, and 10% for Eye Damage 1, based on absence of any eye irritation at 4.75%.
Considering the information on the respiratory irritation it appears that exposure to mists of AMP may cause some respiratory irritation due to the high pH of AMP, however due to the low volatility of AMP and it is not considered appropriate to classify for respiratory inhalation based on the available data.
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