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EC number: 204-709-8 | CAS number: 124-68-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not applicable
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: meets generally accepted scientific standards, well-documented, and acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- not specified
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- 2-amino-2-methylpropanol
- EC Number:
- 204-709-8
- EC Name:
- 2-amino-2-methylpropanol
- Cas Number:
- 124-68-5
- Molecular formula:
- C4H11NO
- IUPAC Name:
- 2-amino-2-methylpropan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): P-1826 (6C29-9B) (AMP)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- The acute oral toxicity of P-1826 (AMP) was determined using young adult male fasted rats.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: saline
- Details on oral exposure:
- Five groups of 10 animals each were administered orally a single dose of P-1826 diluted in saline using equal volumes.
- Doses:
- 2200, 2400, 2800, 3600, 4000 mg/kg (440, 480, 560, 720, 800 mg/ml)
- No. of animals per sex per dose:
- 10 male rats/dose
- Control animals:
- no
- Details on study design:
- The acute oral toxicity of P-1826 was determined using young adult male fasted rats. Five groups of 10 animals each were administered orally a single dose of P-1826 diluted in saline using equal volumes. Animals were observed closely for four hours and daily thereafter for 14 days.
- Statistics:
- Not applicable
Results and discussion
- Preliminary study:
- Not applicable
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD0
- Effect level:
- 2 200 mg/kg bw
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 900 mg/kg bw
- Remarks on result:
- other: + or- 140 mg/kg
- Sex:
- male
- Dose descriptor:
- LD100
- Effect level:
- 4 000 mg/kg bw
- Mortality:
- Doses exceeding 2800 mg/kg orally results in rapid absorbtion into the circulatory system resulting in gross damage to the liver, kidney, spleen, and respiratory system, followed by respiratory collapse. The compound produces irritation to the stomach and duodenum at doses of 2800 mg/kg and greater.
- Clinical signs:
- other: In life observations included: traces of blood on the nostrils, labored breathing, ataxia, and death due to respiratory collapse.
- Gross pathology:
- Necropsy findings (animals that died during the observation period): gas in stomach, inflamed and gaseous duodenum, liver and spleen dark, blood clot in heart.
Necropsy findings (survivors until a scheduled necropsy): No findings in dose levels less than 2800 mg/kg. At 2800 mg/kg, 3 were grossly normal and 3 had a small amount of gas in the stomach with a slightly inflamed duodenum. At 3600 mg/kg, 1 was grossly normal and 1 was grossly normal except a stomach adhered to the liver. - Other findings:
- The following data are reported:
LD0 = 2200 mg/kg
LD50 = 2900 +/-140 mg/kg
LD100 = 4000 mg/kg
Any other information on results incl. tables
Not applicable
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance has low acute oral toxicity.
- Executive summary:
The acute oral toxicity of P-1826 was determined using young adult male fasted rats. Five groups of 10 animals each were administered orally a single dose of P-1826 diluted in saline using equal volumes. Animals were observed closely for four hours and daily thereafter for 14 days. P-1826 is the code designation for 2-amino-2-methyl-l-propanol. Doses exceeding 2800 mg/kg orally results in rapid absorption into the circulatory system resulting in gross damage to the liver, kidney, spleen, and respiratory system followed by respiratory collapse. The compound produces irritation to the stomach and duodenum at doses of 2800 mg/kg and greater. The LD50 was calculated to be 2900 mg/kg bw.
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