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Ecotoxicological information

Short-term toxicity to fish

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Description of key information

Short-term toxicity testing of AMP to fish was assessed in a reliable study with the saltwater plaice (Pleuronectes platessa) according to a protocol similar to EPA OPPTS 850.1075. A GLP study was conducted on the freshwater bluegill sunfish (Lepomis macrochirus) according to: “Methods of Acute Toxicity Tests with Fish, Macroinvertebrates and Amphibians (1975). U.S. EPA, Ecol. Res. Ser. 660/3-75009”. A third study on the Golden Orfe (Leuciscus idus melanotus) is not reliable, as the study does not address the endpoint after 96h of exposure.

Key value for chemical safety assessment

LC50 for freshwater fish:
200 mg/L
LC50 for marine water fish:
193 mg/L

Additional information

The LC50 for freshwater species Lepomis macrochirus (freshwater) was 190 mg/L of the test material containing 95% of AMP, which corrsponds to 200 mg/L AMP. The LC50 for the saltwater Pleuronectes platessa was 184 mg/L of the test material containing 95% AMP, which amount to 193 mg/L AMP. There are no significant different in toxicity between freshwater and saltwater fish. The key study corresponds to the most sensitive test species, the saltwater plaice (Pleuronectes platessa, EC5=184 mg/L test material, 200 mg/L AMP).