2-amino-2-methylpropanol

Toxicity to birds

Administrative data

Endpoint:

toxicity to birds

Type of information:

experimental study

Adequacy of study:

disregarded due to major methodological deficiencies

Study period:

Not applicable

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

documentation insufficient for assessment

Remarks:

conflicting info on test substance identity (AMP or AMPD ?) no clear info on administration method (gavage ? pellets ? capsules ?) no clear info on test species

Data source

Reference

Reference Type:

publication

Title:

The Acute Oral Toxicity, Repellency, and Hazard Potential of 998 Chemicals to One of More Species of Wild and Domestic Birds

Author:

Schafer EW, Bowles WA et al

Year:

1983

Bibliographic source:

Arch. Environm. Contam. Toxicol. 12:355-382

Materials and methods

Principles of method if other than guideline:

acute oral testing in birds with 998 chemicals with LD50 determination

GLP compliance:

no

Test material

Specific details on test material used for the study:

conflicting information about what was tested (end of page 363):
- text describes as 2-Amino-2-methyl-1-propanol (which is CAS 124-68-5, AMP)
- CAS N° indicated is 115-69-5 (which corresponds to 2-Amino-2-methyl-1,3-propanediol, AMPD)
"technical and analytical grade"'

Dose method:

not specified

Remarks:

3 methods listed, not indicated which one was used: - gavage with solution in propylene glycol - pellets - gelatin capsules

Analytical monitoring:

no

Vehicle:

yes

Remarks:

unknown, see above

Test organisms

Test organisms (species):

other: probably Agelaius phoeniceus (Red-winged blackbird) but not clearly stated

Details on test organisms:

Wild-trapped birds were preconditioned to captivity for 2-6 weeks.

Results and discussion

Effect levels

Dose descriptor:

LD50

Effect level:

> 102 mg/kg bw

Basis for effect:

mortality

Remarks on result:

not measured/tested

Remarks:

LD50 in birds was reported to be greater than 102 mg/kg bw. No info about tested doses.

Repellency factors (if applicable):

not determined for this test chemical

Any other information on results incl. tables

No other information was available

Applicant's summary and conclusion

Validity criteria fulfilled:

not specified

Conclusions:

AMP or AMPD (test substance unclear) is reported to have an oral LD50 greater than 102 mg/kg bw in birds (species and administration method not indicated).