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Ecotoxicological information

Toxicity to birds

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Administrative data

Endpoint:
toxicity to birds
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Study period:
Not applicable
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Remarks:
conflicting info on test substance identity (AMP or AMPD ?) no clear info on administration method (gavage ? pellets ? capsules ?) no clear info on test species

Data source

Reference
Reference Type:
publication
Title:
The Acute Oral Toxicity, Repellency, and Hazard Potential of 998 Chemicals to One of More Species of Wild and Domestic Birds
Author:
Schafer EW, Bowles WA et al
Year:
1983
Bibliographic source:
Arch. Environm. Contam. Toxicol. 12:355-382

Materials and methods

Principles of method if other than guideline:
acute oral testing in birds with 998 chemicals with LD50 determination
GLP compliance:
no

Test material

Specific details on test material used for the study:
conflicting information about what was tested (end of page 363):
- text describes as 2-Amino-2-methyl-1-propanol (which is CAS 124-68-5, AMP)
- CAS N° indicated is 115-69-5 (which corresponds to 2-Amino-2-methyl-1,3-propanediol, AMPD)
"technical and analytical grade"'
Dose method:
not specified
Remarks:
3 methods listed, not indicated which one was used: - gavage with solution in propylene glycol - pellets - gelatin capsules
Analytical monitoring:
no
Vehicle:
yes
Remarks:
unknown, see above

Test organisms

Test organisms (species):
other: probably Agelaius phoeniceus (Red-winged blackbird) but not clearly stated
Details on test organisms:
Wild-trapped birds were preconditioned to captivity for 2-6 weeks.

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
> 102 mg/kg bw
Basis for effect:
mortality
Remarks on result:
not measured/tested
Remarks:
LD50 in birds was reported to be greater than 102 mg/kg bw. No info about tested doses.
Repellency factors (if applicable):
not determined for this test chemical

Any other information on results incl. tables

No other information was available

Applicant's summary and conclusion

Validity criteria fulfilled:
not specified
Conclusions:
AMP or AMPD (test substance unclear) is reported to have an oral LD50 greater than 102 mg/kg bw in birds (species and administration method not indicated).