Registration Dossier
Registration Dossier
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EC number: 276-431-5 | CAS number: 72162-23-3 The high-boiling fraction separated by distillation from the products obtained from the reaction of nitric acid with cyclododecanol and cyclododecanone. Composed primarily of dodecanedioic acid, undecanedioic acid, and sebacic acid.
Partition coefficient
Administrative data
Link to relevant study record(s)
Description of key information
Stock solutions of the reference substances (except for ethylmethylketone) at concentrations of approximately 1 g/l in methanol were used. The stock solutions and pure ethylmethylketone were diluted to obtain an end solution of mobile phase (pH 2 or pH 7).
A 1260 mg/l stock solution of the test substance was prepared in methanol. The stock solution was diluted to obtain an end solution of mobile phase pH 2. The final concentration of the test substance solution was 756 mg/l.
A 936 mg/l stock solution of the test substance was prepared in methanol. The stock solution was diluted to obtain an end solution of mobile phase pH 7. The final concentration of the test substance solution was 702 mg/l.
A 5.61 g/l stock solution of the unretained component formamide (99.8%) in methanol was used. The stock solution was diluted to obtain an end solution of mobile phase (pH 2 or pH 7).
PERFORMANCE OF THE TEST
The reference substance and test substance solutions were injected in duplicate. Blank solutions (mobile phase pH 2 or pH 7) were analysed by single injection. The capacity factor (k') of each compound was calculated from its retention time. The log k` values of the references substances were plotted against the known log Pow values. A linear regression program was used to calculate the calibration curve. Linear regression analysis was performed using the least squares method. The log Pow value for the test substance was calculated by substituting its mean log k` in the calibration curve.
Key value for chemical safety assessment
Additional information
The log Pow of the different components in Corfree® M1 diacid mixture at pH 2 and 35°C ranges from < 0.3 to 2.1 (HPLC method). At pH 2, the substance is not-ionised.
The log Pow of the different components in Corfree® M1 diacid mixture at pH 7 and 35°C are < 0.3 (HPLC method). At pH 7, the substance is ionised.
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