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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Administrative data

Link to relevant study record(s)

Description of key information

Corfree® M1 and DDDA data indicates that these similar structured chemicals are unlikely to accumalate in the environment at relevant concentrations.  The Log Kow <3 of these similar chemicals support a lack of bioaccumulation. 

Key value for chemical safety assessment

BCF (aquatic species):
3.16 L/kg ww

Additional information

There is no measured data on bioconcentration for Corfree® M1 or the major ingredient, dodecanedioic acid, available. Based on the measured partition coefficient n-octanol/water (log Kow = 3.2) in the study of Enste-Diefenbach R. (2010), dodecanedioic acid may have a potential for bioaccumulation. However, the BCF was estimated by QSAR (BCFBAF), and the resulting value was 3.16 L/kg wet weight, indicating no potential for bioaccumulation. Additionally dodecanedioic acid was demonstrated in vivo in rats to be rapidly absorbed fom the gastrointesinal tract. The acid was shown to be introduced into the fatty acid catabolism of the organism and was therefore extensively metabolised. Metabolites are incorporated or metabolised to CO2 (Passi et. al. 1983). According to mammalian toxicity data, dodecanedioic acid is not classified as very toxic (T+), Toxic (T) or harmful (Xn) and does not carry the risk phrases R48, R60, R62, R63 or R64. R48 or R60-R64 present in the classification of the substance. Moreover dodecanedioic acid revealed to be readily biodegradable. Therefore, for all the reasons stated above, Corfree® M1 is not expected to accumulate in the environment.