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EC number: 276-431-5 | CAS number: 72162-23-3 The high-boiling fraction separated by distillation from the products obtained from the reaction of nitric acid with cyclododecanol and cyclododecanone. Composed primarily of dodecanedioic acid, undecanedioic acid, and sebacic acid.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- January 28, 1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted using the In Vitro International Corrositex Assay which is a standardized and quantitative in vitro corrosivity test. EU/OECD approval this type of test on July 19, 2006.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: The method to determine United nations' Packing Group
- Deviations:
- no
- Remarks:
- according to the study the testing protocol was followed.
- Principles of method if other than guideline:
- Corrositex uses a synthetic membrane-based or matrix dics system to determine the United Nation packing group classification of chemicals. The results are expressed as a break-through time and correlate with rabbit dermal corrosivity tests. A glass vial filled with a chemical detection fluid is capped by a" proprietary bio-barrier membrane" which is designed to mimic the effect of corrosives on living skin.
Corrositex measures the time required for a test article to pass through a hydrated collagen matrix and supporting filter membrane. As the corrosive sample passes through or destroys this bio-barrier, the underlying liquid Chemical Detection System changes color or texture. The time it takes for the sample to break through the membrane is recorded and compared to a classification chart to determine corrosivity/noncorrosivity for assignment of the proper U.N. Packing Group classification for U.S. DOT or EPA compliance. - GLP compliance:
- not specified
- Remarks:
- GLP statement was not included in this study report, but the procedures for the tests were closely followed.
Test material
- Reference substance name:
- Nitric acid, reaction products with cyclododecanol and cyclododecanone, by-products from, high-boiling fraction
- EC Number:
- 276-431-5
- EC Name:
- Nitric acid, reaction products with cyclododecanol and cyclododecanone, by-products from, high-boiling fraction
- Cas Number:
- 72162-23-3
- Molecular formula:
- UVCB substance. Formula not available
- IUPAC Name:
- Not available for a UVCB
- Details on test material:
- See section 1
Constituent 1
Test animals
- Species:
- other: In Vitro test
- Strain:
- other: In Vitro test
- Details on test animals or test system and environmental conditions:
- No test animals were used in this study. Bio-barrier membrane or matrix discs were prepared and stored at 2.8 degrees celsius for at least 2 hours prior to conducting the assay.
Test system
- Type of coverage:
- other: the vials are open at the top and observed.
- Preparation of test site:
- other: 4 vials are used in this test.
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- Approximately 0.5 grams of the Corfree® M1
- Duration of treatment / exposure:
- >4 hours
- Observation period:
- Vials l-4 were observed for > 240 minutes.
- Number of animals:
- No animals were used in this In Vitro study.
- Details on study design:
- The In Vitro International Corrositex Assay which is a standardized and quantitative in vitro corrosivity test is conducted in 3 steps. Step 1 is the qualifying step. Corfree® M1 (100 mg) is added to the Corrositex test tube to determine if it is compatible with the test system. The tube is shaken and allowed to stand for 1 minute. The tube is observed for a color change or change of consistency at the sample fluid interface. If the amber fluid changes color or consistency, we proceed to Step 2. If a physical change is not observed the substance is not suitable for the Corrositex system. Step 2 is where the categorize of cut-off times for the sample is established. Corfree® M1 (100 mg/vial) is added to two Corrositex test tube which are capped and shaken until mixed. If a color change is noted in either tube the color is matched to a corresponding color chart on the Corrositex Testing Protocol Poster. The appropriate category is assigned according to the color found on the poster. If no color is observed in either tube 2 drops of a confirm reagent is added to Tube B, the tube is shaken until mixed. The resulting color is matched to a corresponding color chart on the Corrositex Testing Protocol Poster. The appropriate category is assigned according to the color found on the poster. Step 3 is the classification step used to determine the appropriate Packing Group. Several vials (4) are used for sample replicate testing. There is a positive and negative control. Corfree® M1 (500 mg) is added to top of the bio-barrier disc; the timer is started the instant the test substance is applied. The vials are observed for changes in the membranes' structure by colormetrics. The category assigned and the mean value of the breakthrough time for all 4 samples replicate vials determine the packing group.
Results and discussion
In vivo
- Irritant / corrosive response data:
- No breakthrough occured in Vials 1-4. Under the conditions of this test, Corfree® M1 was not a corrosive substance and was assigned to non-corrosive.
- Other effects:
- No other effects were observed.
Any other information on results incl. tables
No other information is available on this test.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Corfree® M1 was not a corrosive substance and was assigned to non-corrosive.
- Executive summary:
Dermal Irritation (DuPont, 1999): In a non-GLP, non-guideline study, a membrane disk containing the bio-barrier matrix was placed into a chemical detection system (CDS) vial. Approximately 0.5 grams of the Corfree® M1 (consisting of 46 wt% Dodecanedioic acid, 31 wt% Undecanedioic acid, 5 wt % Sebacic acid and 11 wt% other dibasic acids), ground with a mortar and pestle, was placed on the top of the disc. The vial was then observed for a change in the CDS. This procedure was followed for each of 4 test vials. Vial 5 was similarly treated with a positive control (sulfuric acid) and Vial 6 was similarly treated with a negative control (citric acid). Vials l-4 were observed for > 240 minutes.
The test substance did not pass through any of the membranes. It was concluded that Corfree® M1 was not a corrosive substance.
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