Registration Dossier
Registration Dossier
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EC number: 276-431-5 | CAS number: 72162-23-3 The high-boiling fraction separated by distillation from the products obtained from the reaction of nitric acid with cyclododecanol and cyclododecanone. Composed primarily of dodecanedioic acid, undecanedioic acid, and sebacic acid.
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
In the Guinea pig maximization test with dodecanedioic acid (CAS# 693-23-2) the read-across material for Corfree® M1 it was demonstrated after intradermal and epicutaneous inductions that none of the 20 guinea pigs tested exhibited positive response 24 hours (48 hours) after epicutaneous challenge. Under the conditions of the study dodecanedioic acid or or structurely similar chemicals are not expected to cause skin sensitisation.
Migrated from Short description of key information:
A key read-across study with dodecanedioic acid (CAS# 693-23-2) demonstrated that Corfree® M1 (CASRN: 72162-23-2) is not expected to be a skin sensitizer.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
No study available
Migrated from Short description of key information:
No study available
Justification for classification or non-classification
There was no indication for a sensitising potentialin a maximisation test according to Magnusson and Kligman.
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