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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Experimental studies on oral and dermal acute toxicity are available. Corfree has very low toxicity upon acute exposure.
Oral: LD50 (males/female rats): > 5,000 mg/kg bw
Dermal: LD50 (males/ rabbits): > 6,000 mg/kg bw
Inhalation:LC50 (male rats/4h) : No data

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
discriminating dose
5 000 mg/kg bw

Acute toxicity: via inhalation route

Link to relevant study records
acute toxicity: inhalation
Data waiving:
exposure considerations
Justification for data waiving:
Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
6 000 mg/kg bw

Additional information

Corfree M1 has very low toxicity by the oral or dermal route. A dermal LD50greater than 6,000 mg/kg was reported for the the major chemical (dodecanedioic acid) in Corfree. An oral LD50greater than 5000 mg/kg was reported for Corfree M1. No data on acute toxicity upon inhalation are available. However, since the vapour pressure of dodecanedioic acid, the read across chemical, is very low (1.5 x 10E-8 Pa) exposure via the inhalation route is predicted to be not relevant and a study on inhalation toxicity can be waived. Also, Corfree® M1 (> 95%) is composed of large particles (400-2000um diameter) and inhalation is not expected to be an issue.

Justification for selection of acute toxicity – inhalation endpoint
The potential for inhalation exposures to Corfree® M1 during production is expected to be negligible, particularly up to the time that the product is dehydrated, flaked, and dropped into a hopper car loading bin. Corfree® M1 (> 95%) is composed of large particles (400-2000um diameter) with only <0.5% of the substance in the inhalable range (<100um). Inhalation is not a significant route of exposure for these large size particle substances.

Justification for classification or non-classification

Corfree® M1 (CASRN: 72162-23-2) based on the results of oral ( LD50 males/female rats > 5,000 mg/kg bw) and dermal (LD50 males/ rabbits > 2,000 mg/kg bw) has very low toxicity. Inhalation is not relevant because of low vapour pressure. Therefore, classification regarding acute toxicity is not warranted.