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EC number: 276-431-5 | CAS number: 72162-23-3 The high-boiling fraction separated by distillation from the products obtained from the reaction of nitric acid with cyclododecanol and cyclododecanone. Composed primarily of dodecanedioic acid, undecanedioic acid, and sebacic acid.
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
A 48-h acute fish test was conducted for the read-aross chemical, dodecanedioic acid, by Scheubel J.R. and Scholz N. (1987), using DIN 38412 part 15 method, with Leuciscus idus (static). Concentrations: 200; 500; 1000 mg/L disodium salt were tested. A second acute fish test (48 h) conducted by Scheubel J.R. (1985) studied the toxicity of dodecanedioic acid on Leucisus idus (determined in a static test according to the DIN 38412 part 15 method). Concentrations: 500; 600; 800 mg/L were tested.
An acute toxicity study (48h) was conducted by Wind T. and Mühlberg B. (1982) according to the DIN 38412 L 15 method, with Leuciscus idus (10 fish in 1000 mg dodecanedioic acid /L nominal concentration). It was performed under static conditions with one replicate per concentration level. No effects were observed on Leuciscus idus in any of the three tests. The lowest LC50 (48 hours) was >800 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- mg/L
Marine water fish
Marine water fish
- Effect concentration:
- mg/L
Additional information
The results are summarised in the following table:
| Species | Endpoint (exposure duration) | Exposure concentration | Reference |
| Leuciscus idus | LC50(48 h) | > 840 mg/L | Scheubel J.R., Scholz N. (1987) |
| Leuciscus idus | LC50(48 h) | > 800 mg/L | Scheubel J.R. (1985) |
| Leuciscus idus | LC50(48 h) | > 1000 mg/L | Wind T., Mühlberg B. (1982) |
The available studies indicate that dodecanedioic acid concentrations up to 1000 mg/L are not toxic to fish. However, taking into considaration that no analytical monitoring was conducted and that the water solubilty is between 30 mg/L and 40 mg/L the endpoint that should be considered for risk assessment purposes should be much lower than presented above .
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