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EC number: 276-431-5 | CAS number: 72162-23-3 The high-boiling fraction separated by distillation from the products obtained from the reaction of nitric acid with cyclododecanol and cyclododecanone. Composed primarily of dodecanedioic acid, undecanedioic acid, and sebacic acid.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
A 48-h acute fish test was conducted for the read-aross chemical, dodecanedioic acid, by Scheubel J.R. and Scholz N. (1987), using DIN 38412 part 15 method, with Leuciscus idus (static). Concentrations: 200; 500; 1000 mg/L disodium salt were tested. A second acute fish test (48 h) conducted by Scheubel J.R. (1985) studied the toxicity of dodecanedioic acid on Leucisus idus (determined in a static test according to the DIN 38412 part 15 method). Concentrations: 500; 600; 800 mg/L were tested.
An acute toxicity study (48h) was conducted by Wind T. and Mühlberg B. (1982) according to the DIN 38412 L 15 method, with Leuciscus idus (10 fish in 1000 mg dodecanedioic acid /L nominal concentration). It was performed under static conditions with one replicate per concentration level. No effects were observed on Leuciscus idus in any of the three tests. The lowest LC50 (48 hours) was >800 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- mg/L
Marine water fish
Marine water fish
- Effect concentration:
- mg/L
Additional information
The results are summarised in the following table:
Species | Endpoint (exposure duration) | Exposure concentration | Reference |
Leuciscus idus | LC50(48 h) | > 840 mg/L | Scheubel J.R., Scholz N. (1987) |
Leuciscus idus | LC50(48 h) | > 800 mg/L | Scheubel J.R. (1985) |
Leuciscus idus | LC50(48 h) | > 1000 mg/L | Wind T., Mühlberg B. (1982) |
The available studies indicate that dodecanedioic acid concentrations up to 1000 mg/L are not toxic to fish. However, taking into considaration that no analytical monitoring was conducted and that the water solubilty is between 30 mg/L and 40 mg/L the endpoint that should be considered for risk assessment purposes should be much lower than presented above .
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