Registration Dossier
Registration Dossier
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EC number: 276-431-5 | CAS number: 72162-23-3 The high-boiling fraction separated by distillation from the products obtained from the reaction of nitric acid with cyclododecanol and cyclododecanone. Composed primarily of dodecanedioic acid, undecanedioic acid, and sebacic acid.
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Assessing the toxicity to aquatic invertebrates, Daphnia magna was exposed to Corfree® M1 for 48 hours. The experiment was conducted according to OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test). The test gave a 48-h EC50 value of greater than 120 mg/L.
Key value for chemical safety assessment
Additional information
The acute toxicity of Corfree® M1 (also known as H-25313) to unfed Daphnia magna neonates, less than 24 hours old at test start, was determined in an unaerated, 48-hour, static test. The test was conducted in accordance with the Organisation for Economic Co-Operation and Development (OECD) Guideline for Testing Chemicals: 202; the European Economic Community 92/69 Annex V - Method C.2; and the United States Environmental Protection Agency, Office of Toxic Substances.
The study was conducted with five concentrations of H-25313 and a dilution water control at a mean temperature of 20.6°C (range of 20.2-20.9°C). Four replicates with 5 daphnids per replicate were used per test substance concentration and control. Exposure of daphnids to nominal H-25313 concentrations of 7.5, 15, 30, 60, and 120 mg/L resulted in 0, 5, 0, 0, and 0% immobility, respectively, at the end of 48 hours. No immobility was observed in the water control daphnids. The highest nominal concentration causing no immobility at test end was 120 mg/L. The lowest nominal concentration causing 100% immobility at test end was greater than 120 mg/L. The 48-hour EC50, based on nominal concentrations of H-25313 and immobility, was greater than 120 mg/L.
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