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EC number: 203-127-1
CAS number: 103-60-6
The subchronic dermal toxicity of the test material was investigated
following a procedure in line with that noted in the standardised
guideline OECD 411. During the study groups of 12 male and 12 female
rats were dosed daily with test material via topical application under
an occlusive dressing, for a period of 6 hours per day for 13
consecutive weeks. The groups were dosed at a constant volume of 2 mL/kg
bw at concentrations of 100, 300 and 1000 mg/kg bw/day in diethyl
phalate. A vehicle control was run concurrently for comparison.
Under the conditions of the study there were no notable intergroup
differences or toxicologically significant effects noted when assessing
changes in; body weight, food consumption, water consumption,
haematology, clinical chemistry, urinalysis, organ weights, necropsy
findings or histological findings. Transient incidences of slight
desquamation and erythema were observed, in all animals at similar
incidence and severity.
Overall, exposing rats to the test material for 13 weeks with at dose
levels of up to 1000 mg/kg bw/day produced no notable findings. The NOEL
was therefore taken to be > 1000 mg/kg bw/day.
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