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EC number: 203-127-1
CAS number: 103-60-6
Table 2: Individual Bodyweights
*Individual with the cavity in the right kidney.
The acute dermal toxicity of the test material was determined in a study
conducted in compliance with standardised guidelines OECD 402 and EU
Method B.3. During the study, two animals (one male and one female) were
given a single, 24 -hour semi-occluded dermal application of the
undiluted test material to intact skin at a dose level of 2000 mg/kg bw.
Based on the results of the initial test, a further group of four males
and four females was similarly treated. Clinical signs and bodyweight
development were monitored during the study. All animals were subjected
to gross necropsy.
Under the conditions of the study, there were no deaths or overt signs
of systemic toxicity. There were no signs of dermal irritation and all
animals showed expected gains in bodyweight over the study period. At
necropsy a cavity was noted in the right kidney of one male but this was
considered to be a genetic defect and not related to treatment with the
test material. No abnormalities were noted at necropsy of the remaining
animals. In consideration of these findings the LD50 was determined to
be greater than 2000 mg/kg bw.
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