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EC number: 203-127-1
CAS number: 103-60-6
Table 2: Total Irritation Scores
Table 3. Macroscopic Findings For Sites Exposed to the Test Material
The skin irritation potential of the test material was investigated
according to a methodology similar to that of OECD 404. During the study
0.5 mL of the undiluted test material was applied to the clipped dorsum
of 8 rabbits for 4 hours under a semi-occlusive patch. The irritation
reactions were assessed immediately after removal of the patch and after
24, 48 and 72 hours.
During the course of the study a single application of test material was
seen to produce ‘marginal’ erythema and ‘slight’ edema in five out of
eight animals at 24 hours. By 48 hours and 72 hours ‘marginal’ erythema
and edema was observed in between two and four out of eight animals. The
scores assigned in this study are roughly equivalent to a score of 1
according to the Draize scale (1977).
The response was broadly similar to that produced by the control,
diethyl phthalate, but considerably less than that produced by the
positive controls, cyclamen aldehyde and geraniol.
Under the conditions of the study, the test material was considered to
be slightly irritating; however the elicited reaction was below the
limits of classification.
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