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EC number: 203-127-1
CAS number: 103-60-6
LC50 13.3 mg/L, Brachydanio rerio, EU Method C.1, OECD 203, Caspers (1992).
The acute toxicity of the test material to fish was investigated in a
key study (Caspers, 1992) using Brachydanio rerio (zebra fish) in
accordance with GLP and the standardised guidelines EU Method C.1 and
OECD 203. The freshwater fish were exposed to the test material at a
range of concentrations 7.8 to 44 mg/L, and a blank control run in
parallel. Based on the weighed test material, a 40-99% decrease in
concentration was observed after 24 hours, measured as the sum of test
material and the phenoxyethanol hydrolysis products in the 11 and 31
mg/L exposure groups. Recovery of the test material was less than 80%
due to test material hydrolysis to phenoxyethanol, therefore the results
are based on nominal test concentrations. Under the conditions of the
test, mortality and clinical signs of toxicity were first observed at a
test concentration of 16 mg/L. The LC0 and LC100 values were determined
to be 11 mg/L and 16 mg/L respectively. The LC50 was calculated to be
13.3 mg/L, based on the geometric mean of the LC0 and LC100.
The study was performed in line with GLP and accepted guidelines,
however the reporting was incomplete. A sufficient level of detail was
available to assess the quality of the presented results and accordingly
the study was assigned a reliability score of 2 in line with the
principles for assessing data quality set out in Klimisch (1997).
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