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EC number: 203-127-1
CAS number: 103-60-6
Table 1. Mortalities
Dose Level ml/kg bw
No. of Dead Mice/No. of Animals Treated
The acute oral toxicity of the test material was determined by gavage in
4-5 week old white mice at 3 dose levels using graded volumes of the
test material, 10.0, 5.0 and 2.0 mL/kg bw. Animals were observed for up
to 7 days after exposure. All animals dying were autopsied and those
surviving until termination were sacrifices and examined post mortem
after 7 days. Two mice were dosed at the high and low dose levels and
six for the middle dose level. Equal numbers of males and females were
During the study both mice dosed with 10 mL/kg, four of the six mice
dosed with 5 mL/kg and the one male mouse dosed at 2 mL/kg died within
18-24 hours of treatment. Mice dosed at all three dose levels were
drowsy, showing signs of stress, and exhibiting laboured breathing
within 30 minutes. Within 1 hour of treatment mice were hypothermic.
Within 2 hours of treatment the mice dosed at 10 mL/kg were comatose and
those animals dosed at 2 and 5 mL/kg were semi-comatose. The surviving
female mice recovered within 48 hours following treatment. Autopsy of
the animals that died revealed distension of the stomach due to the
presence of orange/yellow fluid. The stomach and intestines were very
pale and the ileum was irritated and haemorrhaging present in some
animals. These mice also exhibited pale livers and kidneys. The
surviving females were normal in appearance at autopsy.
The dose level was converted from mL/kg bw to mg/kg bw, for
classification, based on the specific gravity of the test material
reported in this study.
Under the conditions of the study the approximate LD50 of the test
material was determined to be between 2060 and 5015 mg/kg bw.
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