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EC number: 203-127-1
CAS number: 103-60-6
Table 2: Individual irritation scores
Rabbit Number and Sex
Initial Pain Reaction
Time After Treatment
Degree of opacity
Area of Cornea Involved
+ Local anaesthetic (one drop of 0.5 % Tetracaine hydrochloride)
Table 3: Bodyweights and bodyweight changes
Individual Bodyweight (kg)
Bodyweight Change (kg)
The irritancy potential of the test material to the eye of the New
Zealand White rabbit was evaluated in a GLP compliant study designed to
be compatible with OECD 405 and EU Method B.5. Undiluted test material
(0.1 mL) was instilled into the eye of two rabbits. After the initial
pain reaction of the first rabbit, the test in the second rabbit was
performed with a local anaesthetic. The rabbits were observed at 1, 24,
48 and 72 hours for signs of ocular irritation. Minimal conjunctival
irritation was noted in both animals an hour post-instillation. One
treated eye appeared normal at the 24 hour observation, and the other
appeared normal at the 48 hour observation. Under the conditions of the
test, the test material is considered to be non-irritating to the New
Zealand White rabbit eye.
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