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EC number: 202-617-2
CAS number: 97-90-5
All seven methacrylate esters were rapidly converted to MAA in
whole rat blood and rat liver microsomes. Hydrolysis half-lives ranged
from 1.56 to 99 minutes, and from 0.06 to 4.95 minutes for blood and
liver microsomes, respectively. The incubations in whole rat blood and
rat liver microsomes were performed on three separate days with MMA
included as a positive control on each day. Table 6 shows elimination
rates (ke), intrinsic clearance (Clint) and half-life values
for each molecule in whole rat blood and rat liver microsomes at 0.25 mM
Rat liver microsome hydrolysis rates for the positive control
(MMA) were somewhat variable between days. This was likely due to the
rapidity of hydrolysis of MMA. Often, measurable levels of MAA were
present even in the zero minute samples and the substrate was completely
hydrolyzed by 2 minutes. This made it difficult to accurately calculate
hydrolysis rates for MMA in these experiments. However, generally the
calculated rates were similar to rates for hydrolysis for MMA reported
previously (Jones, 2002; Mainwaring et al., 2001) and confirmed that the
in vitro test systems were enzymatically active for each day of
incubation experiments. The remaining six molecules exhibited rat liver
microsome hydrolysis rates approximately 10 fold lower than
MMA. However, all seven molecules were completely, or nearly completely,
hydrolyzed to MAA within 15 minutes incubation.
R. D .O. (2002). Using physiologically based pharmacokinetic modeling to
the pharmacokinetics and toxicity of methacrylate esters. Thesis
to theoffor the degree of Doctor of Philosophy
the Faculty of Medicine, Dentistry, Nursing and Pharmacy.
G., Foster, J. R.,, V., and Green, T. (2001). Methyl methacrylate
in rat nasal epithelium: studies of the mechanism of action and
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