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EC number: 202-617-2
CAS number: 97-90-5
2-Hydroxyethyl methacrylate was studied for oral toxicity in rats in an
OECD combined repeat dose and reproductive/developmental toxicity
screening test at doses of 0, 30, 100, 300 and 1000 mg/kg/day. One male
and 6 females of the 1000 mg/kg group (12 animals of each sex) died
during the treatment period. In the males, BUN was elevated or tended to
be high at 30 mg/kg or more, and the relative kidney weights were
increased at 100 mg/kg or more. Salivation, suppression of body weight
gain, decrease in food consumption, iucreased K, C1 and inorganic
phosphorous, decreased triglyceride, increased relative liver weights,
dilatation of renal tubules and collection tubules in the kidney were
seen at 1000 mg/kg. In the females, the relative kidney weights were
elevated or tended to be high at 100 mg/kg or more. Salivation, decrease
in locomotor activity, adoption of a prone position, lacrimation, soiled
fur, hypothermia, bradypnea, suppression in body weight gain, decrease
in food consumption, increases of absolute and relative kidney weights,
neutrophil cellular infiltration in the papilla and medulla and massive
malacia in the medulla oblongata were seen at 1000 mg/kg. The NOELs for
repeat dose toxicity are considered to be less than 30 mg/kg for males,
and 30 mg/kg for females.
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