Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
dermal absorption
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
QSAR prediction

1. SOFTWARE
no software used

2. MODEL (incl. version number)
The prediction model used in this investigation for a set of methacrylate chemicals is based on an established model (Potts and Guy, 1992).

3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
not stated in report

4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
The “Relative Dermal Absorption” potential assigned to the predicted skin flux for methacrylate data is an arbitrary estimation of skin penetration potential, and is not a regulatory or OECD approved classification. It is based on several hundred chemicals tested in the same human skin model at the Central Toxicology Laboratory and Dermal Technology Laboratory. This database includes a wide variety of pharmaceutical, agrochemical and industrial chemicals tested over a 20 year period. The dermal absorption potential of a particular chemical substance is placed into one of six categories based on its skin permeability coefficient or its predicted (or actual) absorption rate

5. APPLICABILITY DOMAIN
not explicitely stated in the report

6. ADEQUACY OF THE RESULT
not explicitely stated in the report

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2013
Report date:
2013

Materials and methods

Principles of method if other than guideline:
Prediction of the skin penetration characteristics using the physicochemical properties used as a first level assessment of the ability of chemical to cross the human epidermis based on: Potts RO and Guy RH (1992). Predicting Skin Permeability. Pharm. Res. 9(5): 663-669
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethylene dimethacrylate
EC Number:
202-617-2
EC Name:
Ethylene dimethacrylate
Cas Number:
97-90-5
Molecular formula:
C10H14O4
IUPAC Name:
ethane-1,2-diyl bis(2-methylacrylate)

Test animals

Species:
other: human skin QSAR
Details on test animals or test system and environmental conditions:
Prediction of the skin penetration characteristics using the physicochemical properties used as a first level assessment of the ability of chemical to cross the human epidermis based on: Potts RO and Guy RH (1992). Predicting Skin Permeability. Pharm. Res. 9(5): 663-669
Assumed skin temperature: 32 °C

Results and discussion

Any other information on results incl. tables

Chemical Class

Test Chemical / Compound Identity

Acronym

Molecular Weight

Log P

Predicted Flux (µg/cm2/h)

Relative Dermal Absorption

Multi-func aliph/hydrophob DMA

Ethylene glycol dimethacrylate

EGDMA

198.22

2.4

6.109

Low

 

Applicant's summary and conclusion

Conclusions:
Based on the dermal penetration model for human skin the predicted skin penetration for EGDMA is low (6.109 µg/cm²/h).
Executive summary:

Based on the dermal penetration model for human skin the predicted skin penetration for EGDMA is low (6.109 µg/cm²/h).