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EC number: 202-617-2
CAS number: 97-90-5
In an acute dermal toxicity study (Limit
test according to OECD 402), a group of 5 male and 5 female
Wistar Crl: WI(Han) rats (source: Charles River, age: 9 weeks (m) and
13 weeks (f), weight: 231 to 247g (m) and 217 to 229 g (f)), were
given a single dermal dose of undiluted Ethyleneglycol dimethacrylate
(purity: 99.88%) at a dose of 2000 mg/kg bw. Animals were then
observed for 14 days.
Dermal LD50Males/Females =
> 2000 mg/kg bw
Ethyleneglycol dimethacrylate is
practically nontoxic in rats based
on the dermal LD50in rats. The substance has no toxicity
category according to Annex VI to Commission Directive 2001/59/EC,
REGULATION (EC) No 1272/2008 and according to OECD GHS criteria.
There were no treatment related signs of
mortality or signs of toxicity but signs of irritation. All signs of
irritation were reversible within the observation period.
This acute dermal limit test study is
classified as acceptable. It does
satisfy the requirements for an
acute dermal study in the rats
according to OECD 402.
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