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EC number: 202-617-2
CAS number: 97-90-5
Ethyleneglycol dimethacrylate is of low acute oral and dermal toxicity. LD50 is higher than 2000 mg/kg bw in rats.
Table (I) Mortality (mortalities occurred within 5 days p.a.)
Table(II) Weight development
Remark: Except the animals I-9 and III-8 (very haggard animals) all the
other test animals showed at the
end of the post exposure period of 14 days normal body weight gain.
In an pre-guideline
acute oral toxicity study,
groups of fasted male and female SPF Wistar rats were
given a single oral dose of Ethylene glycol dimethacrylate > 98.5 % at
doses of 7.94, 8.89, 10.00, 11.20 and 12.60 ml/kg bw
and observed for 14 days.
= 8.30 ml/kg bw equals ca. 8700 mg/kg bw
GHS Category 5 ranges from 2000 -5000 mg/kg bw and
represents the lowest hazard category for classifying the acute oral
toxicity of a chemical substance. ("Criteria for hazard Category 5 are
intended to enable the identification of the test substances which are
of relatively low acute toxicity hazard but which, under certain
circumstances may present a danger to vulnerable populations". (OECD
guideline 425 annex 4)).
glycol dimethacrylate is of very low oral
on this LD50 test in males and females.
NOTE: Any of data in this dataset are disseminated by the
European Union on a right-to-know basis and this is not a
publication in the same sense as a book or an article in a journal.
The right of ownership in any part of this information is reserved
by the data owner(s). The use of this information for any other,
e.g. commercial purpose is strictly reserved to the data owners and
those persons or legal entities having paid the respective access
fee for the intended purpose.
In an acute dermal toxicity study (Limit
test according to OECD 402), a group of 5 male and 5 female
Wistar Crl: WI(Han) rats (source: Charles River, age: 9 weeks (m) and
13 weeks (f), weight: 231 to 247g (m) and 217 to 229 g (f)), were
given a single dermal dose of undiluted Ethyleneglycol dimethacrylate
(purity: 99.88%) at a dose of 2000 mg/kg bw. Animals were then
observed for 14 days.
Dermal LD50Males/Females =
> 2000 mg/kg bw
Ethyleneglycol dimethacrylate is
practically nontoxic in rats based
on the dermal LD50in rats. The substance has no toxicity
category according to Annex VI to Commission Directive 2001/59/EC,
REGULATION (EC) No 1272/2008 and according to OECD GHS criteria.
There were no treatment related signs of
mortality or signs of toxicity but signs of irritation. All signs of
irritation were reversible within the observation period.
This acute dermal limit test study is
classified as acceptable. It does
satisfy the requirements for an
acute dermal study in the rats
according to OECD 402.
of data in this dataset are disseminated by the European Union on a
right-to-know basis and this is not a publication in the same sense
as a book or an article in a journal. The right of ownership in any
part of this information is reserved by the data owner(s). The use
of this information for any other, e.g. commercial purpose is
strictly reserved to the data owners and those persons or legal
entities having paid the respective access fee for the intended
Ethyleneglycol dimethacrylate is of low
acute oral and dermal toxicity. LD50: 8700 mg/kg bw (oral rat, standard
acute method) is higher than 2000 mg/kg bw in rats. In a recent GLP
limit test performed according to OECD guideline 402, the dermal LD50 of
EGDMA was found to be higher than 2000 mg/kg bw in rats with no
mortality or relevant signs of toxicity.
Compliance to REACh requirements
requirements are covered with reliable studies for all three exposure
routes, all performed with the substance itself.
As oral and dermal LD50 are higher than 2000
mg/kg bw in rats, Ethyleneglycol dimethacrylate is not classified
according to the Annex VI to the Directive 67/548/EEC and the CLP
Regulation (EC) N° (1272-2008) nor according to UN-GHS.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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