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EC number: 202-617-2
CAS number: 97-90-5
Overall primary irritation score (PDII): 0.42 of 8
scores FDA (Draize), 1959,
re-evaluated according to OECD 404
Remarks concerning the study result: The study for acute skin irritation/ corrosion was performed before OECD 404 came into force. For this reason the
test values were reevaluated according to OECD criteria and test scores (erythema, oedema) obtained for the scarified skin were regarded as irrelevant.
In a primary
pre-guideline dermal irritation study New Zealand White rabbits were
dermally exposed (intact and scarified skin) to 0.5 mL undiluted
Ethyleneglycol dimethacrylate for
72 hours. Animals
then were observed for 3 days.
Irritation was scored by the method of Draize et al, 1959.
mean erythema score (average value of the single scores (animals 1-6; erythema; intact
skin, 24h and 72h) was determined to be 0.42 out of 4 and the mean
edema score 0 out of 4. Therefore Ethylene glycol dimethacrylate is
dermal irritant .
Therefore the test substance has not to
be classified - according to GHS classification criteria and
according to Draize-criteria - as non irritant for skin (GHS-hazard
Remarks concerning the study result: The study for skin irritation/
corrosion was performed before OECD 404 came into force.
For this reason the test values were reevaluated according to OECD criteria and test scores (erythema, oedema) obtained for the scarified
skin were regarded as irrelevant.
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