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EC number: 267-051-0
CAS number: 67774-74-7
Table 1: Incidence of Fetal
Total fetuses (litters) with variations
% fetuses (litters) with variations
This OECD 414 study in compleance with GLP
examined the potential developmental toxicity of the test substance.
Groups of 24 mated female rats were exposed to concentrations of 0, 125,
500, and 2000 mg/kg bw/day of test substance by oral gavage during days
6 - 15 of gestation. On day 20 of gestation, the animals were sacrificed
and the uterine contents examined. Pups were removed by caesarean
section and soft tissue and skeletal examinations performed. The LOAEL
for maternal toxicity was 500 mg/kg bw/day based on reduced body weight
gain. The NOAEL for maternal toxicity was 125 mg/kg bw/day. The LOAEL
for embryotoxicity was also 500 mg/kg bw/day based on increased
incidence of incomplete ossification. The NOAEL for embryotoxicity was
also 125 mg/kg bw/day. Since embryotoxicity was seen at doses that were
toxic to the maternal animals, the test substance is not classified as
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