Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 267-051-0
CAS number: 67774-74-7
Read-across to 109-d OECD TG 416 study in
rats, NOAEL: 50 mg/kg bw/d;
Read-across to 28-d OECD TG 407 equivalent
study in rats, LOAEL: 125 mg/kg bw
In this study in accordance with OECD TG 416
and in compliance with GLP the effects of repeated exposure to the test
substance was examined. Groups of 30 female and 30 male rats were
exposed to concentrations of 0, 5, 50 and 500 mg/kg day of test
substance by oral gavage beginning ten weeks before mating. Animals were
then mated. The resulting generation was also exposed to the test
substance and mated. Exposure continued through the mating period, and
in females through the gestation and lactational periods. Males were
exposed for a total of 105 days, and females 127 days. All animals were
sacrificed and necropsied after exposure. During the study, animals were
observed for clinical signs, mortality, and body weight. The NOAEL was
50 mg/kg/day and the LOAEL was 500 mg/kg/day based on reduced weight
gain in the high dose group.
In this study in compliance with GLP and
similar to OECD TG 407 the effects of dietary exposure of rats to the
test substance were assessed. Groups of rats were given diets containing
0, 2500, 5000, 7500, or 20000 ppm test substance for 28 days. Animals
were observed for food consumption and body weight changes. At the end
of the study, the animals were sacrificed and examined for gross
pathology. Reduced food consumption and body weight gain was noted at
all dose levels. The NOAEL was < 2500 ppm in the diet. The LOAEL was
2500 ppm in the diet. No abnormalities were seen in the gross pathology
Two experimental studies have been conducted
that provide information on the repeated dose toxicity of the test
substance. At very high daily dietary doses to the test substance in a
28 -day study, rats exhibited reduced food consumption and body weight
gains beginning at the lowest dose of 2500 ppm. No other effects or
abnormalities were observed. In rats exposed to daily oral gavage doses
ranging from 5 to 500 mg/kg bw/day of the test substance through two
generations (109 days, NOAEL = 50 mg/kg bw/d), no adverse effects were
observed except for reductions in body weight gain at the highest
dose. Therefore it is clear that the primary effect of the test
substance at high daily doses is reduced body weight gain, probably as a
function of the poor palatability of the test substance.
Based on the available information
classification upon repeated exposure is not warranted according to EU
Classification, Labelling and Packaging of Substances and Mixtures (CLP)
Regulation No. (EC) 1272/2008
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Niniejsza strona używa plików cookies, aby zapewnić optymalne korzystanie z naszych stron internetowych.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again