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EC number: 267-051-0
CAS number: 67774-74-7
Table 1: Litter Size and Pup
Litter size (mean)
Pup viability index at birth (%)
Pup survival days 0 - 4 (%)
Pup survival days 0 - 4 (%)1
Pup survival days 4 - 21 (%)
data for litters in which all pups died during the Day 0 - 3 interval.
Table 2: Mean Pup Weights (g)
4 - Precull
4 - Postcull
This study in accordance with OECD 416 and
in compliance with GLP the effects of exposure to the test substance on
reproduction were examined. Groups of 30 female and 30 male rats were
exposed to concentrations of 0, 5, 50 and 500 mg/kg day of test
substance by oral gavage beginning ten weeks before mating. Animals were
then mated. The resulting generation was also exposed to the test
substance and mated. Exposure continued through the mating period, and
in females through the gestation and lactational periods. All animals
were sacrificed and necropsied after exposure. Pups not used for mating
were sacrificed at weaning. During the study, animals were observed for
clinical signs, mortality, and body weight. Pups were examined for
viability and body weight gain. Reproductive indices were also
calculated. The NOAEL for parental toxicity was 50 mg/kg/day and the
LOAEL was 500 mg/kg/day based on reduced weight gain and litter size in
the high dose group. The NOAEL for offspring was 50 mg/kg/day based on
reduced body weight gain and survival in the high and mid-dose groups.
The LOAEL for offspring was 50 mg/kg/day. No effects on fertility were
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