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EC number: 267-051-0
CAS number: 67774-74-7
In this study in accordance with OECD TG 416
and in compliance with GLP the effects of repeated exposure to the test
substance was examined. Groups of 30 female and 30 male rats were
exposed to concentrations of 0, 5, 50 and 500 mg/kg day of test
substance by oral gavage beginning ten weeks before mating. Animals were
then mated. The resulting generation was also exposed to the test
substance and mated. Exposure continued through the mating period, and
in females through the gestation and lactational periods. Males were
exposed for a total of 105 days, and females 127 days. All animals were
sacrificed and necropsied after exposure. During the study, animals were
observed for clinical signs, mortality, and body weight. The NOAEL was
50 mg/kg/day and the LOAEL was 500 mg/kg/day based on reduced weight
gain in the high dose group.
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