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EC number: 203-570-0
CAS number: 108-30-5
Table 2. Survival and mean body
weights of rats in the 13 -week gavage study of succinic anhydride
Mean Body Weights (grams)
Table 3. Liver weights of rats in the
13 -week gavage study of succinic anhydridea
In a subchronic toxicity study performed for
13-weeks similar to OECD TG 408, succinic anhydride (99 %) was orally
administered to 10 Fischer 344 rats/sex/dose in corn oil by gavage at
dose levels of 0, 25, 50, 100, 200, 400 mg/kg bw/day (males) and 0,
12.5, 25, 50, 100, 200 mg/kg bw/day (females). Deaths of 8/10 male rats
that received 400 mg/kg and 4/10 males and 5/10 females that received
200 mg/kg were considerd compound related. At necropsy, the mean body
weights of male rats that received 200 or 400 mg/kg were 9% or 15% lower
than that of vehicle controls, whereas the mean body weights of dosed
and vehicle control female rats were similar. Relative liver weights
were slightly increased for females dosed at 100 or 200 mg/kg bw/day. No
compound-related gross or microscopic lesions were observed. Based on
these results, the NOAEL in this 13-week study was considered to be 100
mg/kg bw/day for male and female rats.
This subchronic toxicity study in rats is
acceptable as it was performed similar to the requirements for a
subchronic oral oral study (OECD 408).
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