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EC number: 203-570-0
CAS number: 108-30-5
Time of Death
Table 2. Summary of body weights
Body weights (mean + SD)
In an acute oral toxicity study performed
according to OECD TG 401, groups of 5 fasted Sprague-Dawley rats/sex
were given a single oral dose of succinic anhydride by gavage at doses
of 1214, 1500, 1854, 2291, 2832 and 3500 mg/kg bw and observed for at
least 14 days.
For male rats, cumulative mortality at dose
levels of 1214, 1500, 1854, 2291, 2832, and 3500 mg/kg was 0/5, 1/5,
2/5, 3/5, 3/5 and 5/5, respectively. For female rats, cumulative
mortality at the same dose levels was 1/5, 3/5, 3/5, 5/5, 5/5 and 5/5,
The oral LD50 value was 2157.2 mg/kg bw for
males and 1510.5 mg/kg bw for females. The combined oral LD50 was 1794.9
Clinical signs included decreased activity
in males at dose levels of 1500 mg/kg and higher. Soft stools were
reported for males dosed at 2291 mg/kg and ataxia was observed for males
at the two highest dose levels.
In females, decreased activity was observed
at all dose levels. Soft stools were observed in females dosed at 1214
mg/kg and ataxia was observed at doses of 1500 mg/kg and higher.
Black pylorus in stomach and intestines
containing a blood-like substance were seen in males at doses of 2291
mg/kg and above and in females at doses of 1854 mg/kg and higher.
At the highest dose in males, green areas on
the lungs were seen at necropsy. In females, these effects were observed
at doses levels of 2291 and 3500 mg/kg.
Succinic anhydride is of low toxicity based
on the combined LD50 of 1794.9 mg/kg bw. Classification to Category 4
for acute oral toxicity is warranted according to the CLP criteria as
set out in Regulation (EC) 1272/2008.
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